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Rabbit Polyclonal PHF17(N-term) Antibody

  • 中文名： PHF17 (N-term)抗体
  • 别    名： Protein Jade-1, Jade family PHD finger protein 1, PHD finger protein 17, JADE1, KIAA1807, PHF17
货号: IPDX31285
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein Jade-1, Jade family PHD finger protein 1, PHD finger protein 17, JADE1, KIAA1807, PHF17
Entrez GeneID79960
WB Predicted band size95.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PHF17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-51 amino acids from the N-terminal region of human PHF17.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PHF17 (N-term)抗体的3篇参考文献示例(注：以下文献为虚拟示例，实际引用需根据真实文献调整)：

1. **"PHF17 regulates chromatin remodeling and cancer progression through histone modification"**

*Smith A, et al. (2018)*

摘要：本研究利用PHF17 (N-term)抗体进行Western blot和免疫共沉淀实验，发现PHF17通过其N端结构域与组蛋白甲基转移酶复合物相互作用，促进染色质重塑，并在肾癌中异常高表达，与患者预后不良相关。

2. **"PHF17 is essential for maintaining pluripotency in embryonic stem cells"**

*Jones B, et al. (2020)*

摘要：通过PHF17 (N-term)抗体的免疫荧光和ChIP-seq分析，作者揭示PHF17通过结合多能性基因启动子区(依赖其N端结构域)维持胚胎干细胞的自我更新，敲低PHF17导致多能性丧失。

3. **"PHF17 expression correlates with aggressive subtypes of germ cell tumors"**

*Lee C, et al. (2021)*

摘要：利用PHF17 (N-term)抗体的免疫组化分析临床样本，发现PHF17在恶性生殖细胞肿瘤中特异性高表达，且其表达水平与肿瘤转移和化疗耐药性显著相关，提示其作为潜在生物标志物。

4. **"Structural and functional analysis of PHF17 N-terminal domain in DNA damage repair"**

*Zhang Y, et al. (2019)*

摘要：通过PHF17 (N-term)抗体的蛋白质截断实验，证实其N端结构域对DNA损伤修复至关重要，该区域缺失导致同源重组修复缺陷，并增加细胞对放疗的敏感性。

背景信息

The PHF17 (N-term) antibody is designed to target the N-terminal region of PHF17 (PHD Finger Protein 17), also known as Jade1. a protein implicated in chromatin remodeling, transcriptional regulation, and cellular signaling. PHF17 belongs to the PHD finger protein family, characterized by conserved zinc-binding domains that mediate interactions with histone modifications or other chromatin-associated proteins. Studies suggest PHF17 plays roles in DNA damage response, cell cycle control, and apoptosis, potentially acting as a tumor suppressor or oncogene depending on cellular context. It interacts with components of the VHL (von Hippel-Lindau) tumor suppressor complex and modulates HIF (hypoxia-inducible factor) signaling, linking it to oxygen-sensing pathways and cancer progression. The antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study PHF17 expression, localization, and protein interactions. Its specificity for the N-terminal region allows detection of full-length PHF17 or truncation variants, which may have distinct biological functions. PHF17 dysregulation has been observed in renal, prostate, and other cancers, making this antibody a tool for exploring its diagnostic or therapeutic potential. Validation often includes knockout cell lines to confirm target specificity. Research utilizing this antibody contributes to understanding PHF17's role in epigenetic regulation and disease mechanisms.

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