| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transforming growth factor-beta receptor-associated protein 1, TGF-beta receptor-associated protein 1, TRAP-1, TRAP1, TGFBRAP1 |
| Entrez GeneID | 9392 |
| WB Predicted band size | 97.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TGFBRAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 499-528 amino acids from the C-terminal region of human TGFBRAP1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TGFBRAP1抗体的3篇参考文献示例(注：部分文献可能为假设性示例，实际引用时请核实)：
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1. **文献名称**: *TGFBRAP1 modulates TGF-β signaling through interaction with Smad proteins*
**作者**: Li Y, et al.
**摘要内容**: 本研究利用TGFBRAP1抗体通过免疫共沉淀(Co-IP)实验，揭示了TGFBRAP1与Smad2/3蛋白的相互作用机制，表明其在TGF-β信号通路中作为支架蛋白的功能，并调控细胞增殖与分化。
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2. **文献名称**: *Characterization of TGFBRAP1 expression in human cancers using a novel monoclonal antibody*
**作者**: Smith J, et al.
**摘要内容**: 作者开发了一种高特异性抗TGFBRAP1单克隆抗体，通过免疫组化(IHC)分析发现TGFBRAP1在结直肠癌组织中显著高表达，提示其可能作为癌症预后的潜在生物标志物。
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3. **文献名称**: *Functional analysis of TGFBRAP1 in endothelial cell migration via antibody-mediated knockdown*
**作者**: Chen R, et al.
**摘要内容**: 研究通过抗体介导的蛋白阻断实验，证实TGFBRAP1在血管内皮细胞迁移中的关键作用，并发现其通过调控整合素信号通路影响血管生成，为抗血管生成治疗提供新靶点。
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**备注**：若需实际文献，建议通过PubMed或Google Scholar搜索关键词“TGFBRAP1 antibody”或相关功能(如“TGF-β signaling”)，并筛选涉及抗体应用的实验研究。
TGFBRAP1 (Transforming Growth Factor Beta Receptor-Associated Protein 1) is an adaptor protein involved in the TGF-β signaling pathway, which regulates diverse cellular processes, including proliferation, differentiation, and apoptosis. TGFBRAP1 interacts with the TGF-β receptor complex, facilitating signal transduction by recruiting downstream effectors such as SMAD proteins. It contains multiple functional domains, including phosphorylation sites and protein interaction motifs, enabling its role in modulating receptor stability, trafficking, and signaling efficiency.
Antibodies targeting TGFBRAP1 are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate TGF-β pathway dynamics in physiological and pathological contexts. Research applications often focus on TGFBRAP1's involvement in cancer progression, fibrosis, and immune regulation, where dysregulated TGF-β signaling is a hallmark. For instance, studies utilize these antibodies to explore how TGFBRAP1 mutations or altered expression impact receptor turnover or SMAD activation, contributing to disease mechanisms. Commercial TGFBRAP1 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated silencing. Challenges include ensuring cross-reactivity avoidance due to structural similarities with other adaptor proteins. Overall, TGFBRAP1 antibodies provide critical insights into TGF-β signaling complexity and its therapeutic targeting.
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