| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein BEAN1, Brain-expressed protein associating with Nedd4 homolog, BEAN, BEAN1 |
| Entrez GeneID | 146227 |
| WB Predicted band size | 28.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This BEAN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-73 amino acids from the N-terminal region of human BEAN. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于BEAN(N-term)抗体的模拟参考文献示例(仅供参考，实际文献需通过学术数据库确认)：
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1. **文献名称**：**"Characterization of a Polyclonal Antibody Specific to the N-Terminal Domain of BEAN Protein in Neuronal Tissues"**
**作者**：Thompson, L.K., et al.
**摘要**：本研究开发了一种针对BEAN蛋白N端结构域的多克隆抗体，验证了其在Western blot和免疫荧光中的特异性，并揭示了BEAN在小鼠大脑皮层神经元中的亚细胞定位。
2. **文献名称**：**"N-Terminal Epitope Tagging of BEAN Reveals Its Role in Ubiquitination Pathways"**
**作者**：Zhang, M., & Ito, T.
**摘要**：通过构建N端表位标记的BEAN蛋白，结合特异性抗体，发现BEAN与泛素连接酶NEDD4的相互作用，提示其在蛋白质降解调控中的潜在功能。
3. **文献名称**：**"A Novel Monoclonal Antibody Targeting BEAN’s N-Terminus for Detection in Neurodegenerative Disease Models"**
**作者**：Vargas, D., et al.
**摘要**：报道了一种高亲和力单克隆抗体，特异性识别BEAN蛋白的N端区域，成功应用于阿尔茨海默病模型小鼠的脑组织病理学分析。
4. **文献名称**：**"BEAN N-Terminal Antibody Application in Functional Studies of Circadian Rhythm Regulation"**
**作者**：Chen, W., et al.
**摘要**：利用N端特异性抗体，研究发现BEAN蛋白在哺乳动物生物钟调控中与CLOCK蛋白存在共定位，可能影响昼夜节律相关基因表达。
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**建议**：如需获取真实文献，可通过PubMed或Google Scholar检索关键词如“BEAN antibody N-terminal”“BEAN protein epitope mapping”等，并筛选近年发表的研究。
BEAN (Brain Expressed Associated with NEDD4) antibodies target the N-terminal region of the BEAN1 protein, a molecule implicated in neurological functions and ubiquitination pathways. BEAN1. encoded by the *BEAN1* gene, interacts with NEDD4. an E3 ubiquitin ligase involved in protein degradation and cellular regulation. This interaction suggests BEAN1's role in modulating ubiquitin-dependent processes, potentially influencing neuronal development, synaptic plasticity, or disease mechanisms.
The N-terminal region of BEAN1 contains critical domains for its biological activity, including binding motifs for NEDD4 and other regulatory partners. Antibodies specific to this region (BEAN N-term) are valuable tools for studying protein expression, localization, and post-translational modifications in research models. They are commonly used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to explore BEAN1's function in health and disease.
Interest in BEAN1 has grown due to its potential links to neurological disorders. Studies suggest associations with spinocerebellar ataxia and other neurodegenerative conditions, possibly through dysregulated ubiquitination pathways. BEAN N-term antibodies help elucidate these mechanisms by enabling precise detection of BEAN1 isoforms or cleavage products, which may serve as biomarkers or therapeutic targets. Ongoing research aims to clarify its role in cellular homeostasis and neural networks, underscoring the antibody's utility in both basic and translational neuroscience.
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