| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Hox-4.6, Hoxd-11 |
| WB Predicted band size | 34 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXD11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BNIP2抗体的3篇示例参考文献(注：以下为模拟文献，实际引用时需核实真实来源)：
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1. **标题**: "BNIP2 regulates apoptosis and autophagy in cancer cells via Bcl-2 interaction"
**作者**: Chen L, et al.
**摘要**: 本研究利用特异性BNIP2抗体，通过Western blot和免疫荧光技术，揭示了BNIP2在结直肠癌细胞中通过与Bcl-2蛋白相互作用调控自噬和凋亡的分子机制。抗体验证显示其在肿瘤组织中高表达，并与患者预后相关。
2. **标题**: "Development of a monoclonal antibody against human BNIP2 for diagnostic applications"
**作者**: Wang Y, et al.
**摘要**: 文章报道了一种新型抗人BNIP2单克隆抗体的开发与验证。该抗体在ELISA、免疫组化中表现出高特异性，成功应用于肺癌组织样本的BNIP2蛋白水平检测，证实其在临床诊断中的潜在价值。
3. **标题**: "BNIP2 modulates cytoskeletal dynamics in endothelial cell migration"
**作者**: Kim S, et al.
**摘要**: 通过免疫共沉淀和细胞免疫染色(使用BNIP2抗体)，研究发现BNIP2通过调控Rho GTPase活性影响内皮细胞迁移。抗体特异性实验证实其在多种细胞系中的表达差异，提示其在血管生成中的作用。
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**提示**：实际研究中建议通过PubMed或Google Scholar以“BNIP2 antibody”、“BNIP2 protein detection”等关键词检索最新文献，并关注抗体品牌(如Santa Cruz、Abcam)提供的引用文献列表。
The BNIP2 (Bcl-2/adenovirus E1B 19 kDa-interacting protein 2) antibody is a tool used to study the BNIP2 protein, a member of the Bcl-2 family involved in regulating apoptosis, autophagy, and cellular homeostasis. BNIP2 interacts with anti-apoptotic proteins like Bcl-2 and Bcl-xL, influencing cell survival and death pathways. It also plays roles in cytoskeletal organization and cell migration by binding to small GTPases such as Cdc42. Structurally, BNIP2 contains a BCH domain, enabling protein-protein interactions critical for its diverse functions.
Research highlights BNIP2's involvement in the Hippo signaling pathway, where it modulates YAP/TAZ activity to regulate cell proliferation and organ size. Dysregulation of BNIP2 expression has been linked to cancer progression, including breast, prostate, and gastric cancers, where it may act as either an oncogene or tumor suppressor depending on context. The BNIP2 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and interactions in cellular and tissue samples. Its applications extend to studying hypoxia responses, metabolic stress, and developmental processes. Validating this antibody's specificity is essential, as cross-reactivity with homologous proteins (e.g., BNIP1 or BNIP3) could lead to misinterpretation. Ongoing research continues to explore BNIP2's molecular mechanisms and therapeutic potential in diseases.
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