| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tyrosine-protein phosphatase non-receptor type 2, T-cell protein-tyrosine phosphatase, TCPTP, PTPN2, PTPT |
| Entrez GeneID | 5771 |
| WB Predicted band size | 48.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PTPN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-358 amino acids from the C-terminal region of human PTPN2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PTPN2抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*PTPN2 regulates T cell receptor signaling and restrains autoimmunity*
**作者**：Wiede F, et al.
**摘要**：研究利用PTPN2特异性抗体，发现PTPN2通过调控T细胞受体信号通路抑制自身免疫反应，其缺失导致T细胞过度活化并引发炎症性疾病。
2. **文献名称**：*Targeting PTPN2 in cancer immunotherapy enhances anti-tumor immunity*
**作者**：Manguso RT, et al.
**摘要**：通过抗体介导的PTPN2功能抑制实验，揭示阻断PTPN2可增强肿瘤微环境中T细胞的抗肿瘤活性，为免疫治疗提供新靶点。
3. **文献名称**：*PTPN2 deletion in pancreatic β cells promotes type 1 diabetes by disrupting immune tolerance*
**作者**：Stanford SM, et al.
**摘要**：利用PTPN2抗体检测其在胰岛β细胞中的表达，发现PTPN2缺失导致自身抗原呈递增加，打破免疫耐受并加速1型糖尿病发展。
以上文献均通过实验验证PTPN2抗体的应用，涉及免疫调控、癌症治疗和自身免疫疾病机制研究。
PTPN2 (Protein Tyrosine Phosphatase Non-Receptor Type 2), also known as TCPTP, is a ubiquitously expressed enzyme that regulates cellular signaling by dephosphorylating tyrosine residues on target proteins. It plays a critical role in modulating immune responses, cell growth, and metabolic pathways. PTPN2 is particularly notable for its involvement in downregulating inflammatory signaling cascades, including the JAK-STAT and MAPK pathways, by deactivating key signaling molecules such as STAT1. EGFR, and ERK. Dysregulation of PTPN2 has been linked to autoimmune diseases (e.g., type 1 diabetes, inflammatory bowel disease), cancer, and metabolic disorders.
Antibodies targeting PTPN2 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They enable researchers to detect PTPN2 protein levels via techniques like Western blotting, immunohistochemistry, and flow cytometry. Additionally, these antibodies facilitate investigations into PTPN2’s role in immune cell activation, tumor suppression, and insulin signaling. Recent studies highlight PTPN2 as a potential therapeutic target, with inhibitors or activators explored for cancer immunotherapy and autoimmune disease treatment. Its dual presence in the cytoplasm and nucleus further underscores its complex regulatory mechanisms, making PTPN2-specific antibodies crucial for dissecting its multifaceted roles in health and disease.
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