| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Synaptonemal complex protein SC65, Leprecan-like protein 4, Nucleolar autoantigen No55, LEPREL4, NOL55, SC65 |
| Entrez GeneID | 10609 |
| WB Predicted band size | 50.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SC65 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 361-390 amino acids from the C-terminal region of human SC65. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SC65抗体的3篇示例参考文献(注：以下内容为模拟示例，实际文献需通过学术数据库查询)：
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1. **文献名称**: "SC65: A Novel Lysosomal Antigen Targeted in Melanoma Immunotherapy"
**作者**: Müller, A. et al.
**摘要**: 研究揭示了SC65作为溶酶体膜蛋白在黑色素瘤细胞中的高表达特性，开发特异性抗体用于靶向治疗，体外实验显示抗体可诱导肿瘤细胞凋亡。
2. **文献名称**: "Autoantibody Profiling Identifies SC65 as a Biomarker in Autoimmune Disorders"
**作者**: Chen, L. & Wang, Y.
**摘要**: 通过筛选自身免疫患者血清，发现SC65抗体与系统性红斑狼疮(SLE)显著相关，提示其可能参与疾病病理机制，具备诊断潜力。
3. **文献名称**: "Structural and Functional Analysis of SC65 Interaction with Monoclonal Antibodies"
**作者**: Kim, S. et al.
**摘要**: 利用冷冻电镜解析SC65蛋白与其单克隆抗体的复合物结构，阐明抗原表位，为优化抗体药物设计提供分子基础。
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建议通过 **PubMed** 或 **Google Scholar** 检索关键词“SC65 antibody”、“SC65 autoantigen”获取真实文献。
SC65 antibody, also known as anti-SUMF2. targets the sulfatase-modifying factor 2 (SUMF2) protein, a key regulator of sulfatase enzymes. SUMF2 is a paralog of SUMF1 and functions as a co-factor in the post-translational activation of sulfatases, which hydrolyze sulfate esters in lysosomes and extracellular matrices. These enzymes are critical for metabolic processes, including glycosaminoglycan degradation and hormone biosynthesis.
SC65 antibodies are primarily used in research to study SUMF2's role in cellular metabolism, cancer, and rare genetic disorders. Mutations or dysregulation of sulfatases or their modifiers are linked to lysosomal storage diseases (e.g., mucopolysaccharidoses) and certain cancers. SUMF2 is thought to act as a competitive inhibitor of SUMF1. modulating sulfatase activity and influencing disease progression.
In diagnostic contexts, SC65 antibodies help detect SUMF2 expression levels in tissues or cell lines, aiding in understanding its tissue-specific functions and interactions with SUMF1. Recent studies explore its potential role in neurodegenerative diseases and tumor microenvironments, where sulfatase activity may affect cell signaling or extracellular remodeling.
Overall, SC65 antibody serves as a vital tool for elucidating sulfatase regulation mechanisms and developing therapies targeting sulfatase-related pathologies.
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