| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | N-acetylserotonin O-methyltransferase-like protein, ASMTL, 211-, ASMTL |
| Entrez GeneID | 8623 |
| WB Predicted band size | 68.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ASMTL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-259 amino acids from the Central region of human ASMTL. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ASMTL抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献可能需要通过学术数据库验证)：
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1. **文献名称**：*"Development and Application of a Novel ASMTL-Specific Antibody for Circadian Rhythm Studies"*
**作者**：Miller, J. et al.
**摘要**：研究团队开发了一种高特异性ASMTL多克隆抗体，用于检测小鼠下丘脑组织中的ASMTL蛋白表达。通过免疫印迹和免疫荧光技术，发现ASMTL在调节褪黑素合成通路中具有昼夜节律性表达模式，提示其可能参与生物钟调控。
2. **文献名称**：*"ASMTL as a Potential Biomarker in Colorectal Cancer: Immunohistochemical Analysis Using a Novel Antibody"*
**作者**：Chen, L. et al.
**摘要**：利用新开发的ASMTL单克隆抗体对结直肠癌组织进行免疫组化分析，发现ASMTL在肿瘤细胞中显著高表达，且与患者预后不良相关。研究验证了该抗体的特异性，并探讨了ASMTL在癌症代谢重编程中的作用。
3. **文献名称**：*"Structural Insights into ASMTL Enzyme Function through Antibody-Mediated Crystallization"*
**作者**：Rodriguez, S. et al.
**摘要**：通过ASMTL抗体辅助的蛋白纯化与结晶技术，解析了ASMTL的三维结构，揭示了其甲基转移酶活性位点的关键区域。该抗体还被用于验证ASMTL与底物结合区域的相互作用，为开发靶向抑制剂奠定基础。
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**说明**：若需获取真实文献，建议在PubMed、Web of Science等平台以关键词“ASMTL antibody”“ASMTL protein function”检索，或查阅相关基因功能研究的补充材料(如抗体验证数据)。部分研究可能未直接以ASMTL抗体为核心主题，但会在方法学部分提及其应用。
The ASMTL (Acetylserotonin Methyltransferase-Like) gene, located in the pseudoautosomal region of human X and Y chromosomes, encodes a protein with homology to acetylserotonin methyltransferase (ASMT), a key enzyme in melatonin synthesis. While ASMT catalyzes the final step of melatonin production in the pineal gland, ASMTL's precise biochemical function remains less defined. Studies suggest it may act as a methyltransferase or regulatory protein, potentially influencing spermatogenesis due to its testis-enriched expression.
ASMTL antibodies are primarily used in research to study protein expression, localization, and functional roles. Immunohistochemical analyses reveal ASMTL's cytoplasmic localization in germ cells, supporting its proposed involvement in male reproductive biology. Antibody-based studies have also explored ASMTL's potential association with neurodevelopmental disorders, given melatonin's neurological roles and ASMTL's genetic link to autism spectrum disorders in some population studies.
Recent investigations employ ASMTL antibodies to examine its expression patterns in cancers, particularly germ cell tumors, and its possible regulatory relationships with neighboring genes in the pseudoautosomal region. These tools remain crucial for deciphering ASMTL's contribution to cellular processes and disease mechanisms, though functional characterization is ongoing. Commercial availability of ASMTL antibodies has enabled broader exploration of its pathophysiological significance across multiple research domains.
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