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Rabbit Polyclonal GPHB5 Antibody

  • 中文名: GPHB5抗体
  • 别    名: Glycoprotein hormone beta-5, Thyrostimulin subunit beta, GPHB5, GPB5, ZLUT1
货号: IPDX31246
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGlycoprotein hormone beta-5, Thyrostimulin subunit beta, GPHB5, GPB5, ZLUT1
Entrez GeneID122876
WB Predicted band size14.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis GPHB5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-91 amino acids from the C-terminal region of human GPHB5.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于GPHB5抗体的3篇文献摘要示例(虚构内容,仅供格式参考):

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1. **文献名称**: *Characterization of GPHB5 as a novel glycoprotein hormone subunit*

**作者**: Kudo M, et al.

**摘要**: 该研究首次克隆并鉴定了GPHB5基因,通过抗体免疫印迹和免疫组化技术证实其在哺乳动物垂体及生殖组织中的特异性表达,提示其可能参与激素信号调控。

2. **文献名称**: *GPHB5 antibody reveals its role in testicular development and function*

**作者**: Tao Y, et al.

**摘要**: 利用GPHB5特异性抗体研究发现,该蛋白在小鼠睾丸支持细胞中高表达,敲除模型显示其缺失导致精子发生异常,表明其对雄性生殖系统至关重要。

3. **文献名称**: *GPHB5 as a potential biomarker in ovarian cancer: an immunohistochemical study*

**作者**: Li X, et al.

**摘要**: 通过抗体验证GPHB5在卵巢癌组织中显著上调,其表达水平与患者预后相关,提示其可能作为癌症诊断或治疗的分子靶点。

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注:以上内容为模拟示例,实际文献需通过PubMed/Google Scholar等平台检索。建议使用关键词“GPHB5 antibody”或“GPHB5 function”查找真实文献。

背景信息

The GPHB5 antibody is a research tool designed to target the G protein-coupled receptor HB5 (GPHB5), a member of the adhesion G protein-coupled receptor (aGPCR) family. GPHB5. also known as ADGRB5. is implicated in cellular adhesion, signaling, and tissue development, though its precise biological roles remain under investigation. aGPCRs like GPHB5 are characterized by large extracellular domains involved in cell-cell interactions and intracellular signaling pathways regulating processes such as embryogenesis, immune response, and tumor progression. Antibodies against GPHB5 are primarily used to study its expression, localization, and function in various tissues, including the nervous and cardiovascular systems. Recent studies suggest potential links between GPHB5 dysregulation and diseases like cancer or neurological disorders, driving interest in therapeutic or diagnostic applications. However, research on GPHB5 is still emerging, with most antibodies being polyclonal or monoclonal reagents validated for immunohistochemistry, Western blotting, or flow cytometry. Challenges include limited data on ligand interactions and signaling mechanisms, necessitating further functional studies. The development of GPHB5 antibodies contributes to unraveling the complex roles of aGPCRs in physiology and pathology, potentially opening avenues for targeted therapies.

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