| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Carbohydrate sulfotransferase 9, 282-, GalNAc-4-O-sulfotransferase 2, GalNAc-4-ST2, GalNAc4ST-2, N-acetylgalactosamine-4-O-sulfotransferase 2, CHST9 |
| Entrez GeneID | 83539 |
| WB Predicted band size | 52.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CHST9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human CHST9. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CHST9 (N-term)抗体的3篇参考文献示例(注：文献为虚拟示例，实际研究中请核实具体文献)：
1. **"Characterization of CHST9 Expression in Human Testis Using a Novel N-terminal Specific Antibody"**
- **作者**: Smith A, et al.
- **摘要**: 本研究开发了一种针对CHST9蛋白N端表位的多克隆抗体，通过免疫组化和Western blot验证其在人类睾丸组织中的特异性表达，表明CHST9可能在精子发生中发挥功能。
2. **"CHST9 Sulfotransferase Activity and Its Role in Glycosaminoglycan Modification"**
- **作者**: Lee B, et al.
- **摘要**: 利用N端特异性抗体(CHST9-N1)检测CHST9在多种细胞系中的表达，发现其参与硫酸软骨素的磺酸化修饰，并通过敲低实验证实其对细胞外基质的影响。
3. **"A Comprehensive Analysis of Carbohydrate Sulfotransferases in Cancer: Focus on CHST9"**
- **作者**: Zhang Y, et al.
- **摘要**: 通过CHST9 (N-term)抗体分析肿瘤组织中CHST9的亚细胞定位及表达水平，发现其高表达与乳腺癌患者预后不良相关，提示其可能作为潜在生物标志物。
4. **"Development and Validation of Antibodies for CHST Family Proteins in Epithelial Cells"**
- **作者**: Tanaka K, et al.
- **摘要**: 研究报道了包括CHST9在内的多个磺基转移酶抗体的开发，重点验证了CHST9-Nterm抗体在肠上皮细胞中的特异性，并探讨其在黏膜屏障硫酸化中的潜在作用。
建议通过PubMed或Google Scholar以“CHST9 antibody N-terminal”为关键词检索最新文献以获取真实数据。
The CHST9 (N-term) antibody is a specialized tool designed to target the N-terminal region of carbohydrate sulfotransferase 9 (CHST9), a member of the sulfotransferase family involved in carbohydrate metabolism. CHST9 catalyzes the transfer of sulfate groups to specific carbohydrate structures, notably modifying glycosaminoglycans (GAGs) like chondroitin sulfate, which play roles in cell signaling, adhesion, and extracellular matrix organization. This enzyme is expressed in various tissues, including the brain, gastrointestinal tract, and reproductive organs, and has been implicated in physiological processes such as neuronal development, immune regulation, and mucosal barrier function.
The N-terminal-targeting antibody enables researchers to study CHST9 expression, localization, and function in biological samples. It is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate CHST9’s role in health and disease. Studies suggest CHST9 may contribute to pathological conditions, including cancer progression (e.g., modulating tumor microenvironment interactions) and inflammatory disorders (e.g., regulating leukocyte trafficking). The antibody’s specificity for the N-terminal region ensures recognition of full-length or truncated isoforms, aiding in distinguishing between splice variants or degradation products. Validated applications and species reactivity (e.g., human, mouse) are typically provided by manufacturers, though optimization for experimental conditions is often required. This tool remains critical for elucidating CHST9’s biological significance and therapeutic potential.
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