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Rabbit Polyclonal SSR2 Antibody

  • 中文名: SSR2抗体
  • 别    名: Translocon-associated protein subunit beta, TRAP-beta, Signal sequence receptor subunit beta, SSR-beta, SSR2, TRAPB
货号: IPDX31230
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTranslocon-associated protein subunit beta, TRAP-beta, Signal sequence receptor subunit beta, SSR-beta, SSR2, TRAPB
Entrez GeneID6746
WB Predicted band size20.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis SSR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 amino acids from the C-terminal region of human SSR2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于SSR2抗体的虚构参考文献示例,供参考:


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1. **文献名称**:*Development of a High-Affinity Monoclonal Antibody Against SSR2 for Targeted Cancer Therapy*


**作者**:Miller, T. et al.


**摘要**:本研究报道了一种新型抗SSR2单克隆抗体的开发,通过噬菌体展示技术筛选出高亲和力抗体,并在乳腺癌模型中验证其靶向抑制肿瘤增殖的效果,为癌症治疗提供潜在策略。


2. **文献名称**:*SSR2 Autoantibodies as a Diagnostic Marker in Systemic Lupus Erythematosus*


**作者**:Chen, Y. et al.


**摘要**:通过ELISA检测发现,SSR2自身抗体在系统性红斑狼疮(SLE)患者血清中显著升高,且与疾病严重程度相关,提示其作为SLE新型生物标志物的潜力。


3. **文献名称**:*Structural Insights into SSR2 Epitope Recognition by Neutralizing Antibodies*


**作者**:Watanabe, S. et al.


**摘要**:利用冷冻电镜解析SSR2蛋白与中和抗体的复合物结构,揭示了抗体结合的关键表位,为基于结构的抗SSR2药物设计奠定基础。


4. **文献名称**:*SSR2 Antibody-Drug Conjugate Demonstrates Efficacy in Resistant Lymphoma Models*


**作者**:Patel, R. et al.


**摘要**:构建了SSR2抗体-药物偶联物(ADC),在耐药性淋巴瘤小鼠模型中显示出显著肿瘤消退,证明其作为难治性血液肿瘤治疗方案的可行性。


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注:以上文献为虚构示例,实际引用请查询权威数据库(如PubMed)。

背景信息

The SSR2 (Sulfated Steroid Transport Regulator 2) antibody is primarily used to study the SSR2 protein, a component of the translocon-associated protein (TRAP) complex located in the endoplasmic reticulum (ER). SSR2 facilitates the translocation of nascent polypeptides during protein synthesis and plays a critical role in maintaining ER homeostasis. Research has linked SSR2 to various cellular processes, including protein folding, quality control, and calcium signaling. Dysregulation of SSR2 has been implicated in pathological conditions such as cancer, neurodegenerative diseases, and secretory pathway disorders. The SSR2 antibody is a key tool for detecting the protein via techniques like Western blotting, immunofluorescence, and immunohistochemistry. It aids in elucidating SSR2's expression patterns, interactions with other TRAP complex subunits (e.g., SSR1. SSR3), and its role in diseases. Recent studies suggest SSR2 may influence cancer cell survival by modulating ER stress responses, making it a potential therapeutic target. However, its specific mechanisms remain under investigation. The antibody's development and validation have significantly advanced understanding of ER-associated processes, emphasizing SSR2's importance in cellular proteostasis and disease pathology.

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