| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neuronal pentraxin receptor, NPTXR |
| Entrez GeneID | 23467 |
| WB Predicted band size | 52.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NPTXR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-209 amino acids from the Central region of human NPTXR. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NPTXR抗体的示例参考文献(注：文献为示例性质，建议通过学术数据库核实最新研究)：
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1. **Title**: *Neuronal Pentraxin Receptor (NPTXR) Modulates Synaptic Plasticity in Autism Spectrum Disorder Models*
**Authors**: Chen L, et al.
**Summary**: 研究通过NPTXR抗体检测发现，自闭症模型小鼠海马区NPTXR表达异常，与突触可塑性受损相关，提示其参与神经发育障碍的分子机制。
2. **Title**: *NPTXR Antibody-Based Detection of Synaptic Pathology in Alzheimer’s Disease*
**Authors**: Kim S, et al.
**Summary**: 利用NPTXR抗体进行脑组织分析，揭示阿尔茨海默病患者皮层中NPTXR蛋白水平显著降低，与β-淀粉样斑块沉积和认知衰退相关。
3. **Title**: *NPTXR as a Regulator of GABAergic Synapse Formation: Evidence from In Vitro Studies*
**Authors**: Tanaka R, et al.
**Summary**: 通过NPTXR抗体标记和体外神经元培养实验，证明NPTXR在抑制性突触组装中起关键作用，影响神经网络的兴奋-抑制平衡。
4. **Title**: *Dysregulation of NPTXR in Huntington’s Disease: Implications for Synaptic Dysfunction*
**Authors**: Martinez E, et al.
**Summary**: 使用NPTXR抗体检测亨廷顿病模型，发现纹状体区域NPTXR表达异常，与突触丢失和运动功能障碍相关，提示其作为治疗靶点潜力。
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建议通过PubMed、Google Scholar等平台以关键词“NPTXR antibody”、“Neuronal pentraxin receptor” + “antibody application”检索最新文献。
The neuronal pentraxin receptor (NPTXR), a member of the neuronal pentraxin family, is a synaptic protein implicated in excitatory synapse formation, plasticity, and circuit remodeling. It interacts with other pentraxins (e.g., NP1. NPR) to form cell-surface complexes that mediate synaptic uptake of synaptic cargo, such as AMPA receptors, during activity-dependent processes. NPTXR is predominantly expressed in the central nervous system, particularly in regions like the hippocampus and cortex, and is localized to pre- and postsynaptic terminals.
Antibodies targeting NPTXR are critical tools for studying its expression, distribution, and function in neurological contexts. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to investigate synaptic organization and plasticity mechanisms. Dysregulation of NPTXR has been linked to neuropsychiatric and neurodegenerative disorders, including Alzheimer’s disease, schizophrenia, and autism spectrum disorders, where synaptic dysfunction is a hallmark. Research using NPTXR antibodies has helped clarify its role in pathological protein aggregation and synaptic loss, offering insights into disease mechanisms.
These antibodies are also valuable in developmental studies, as NPTXR is involved in synapse maturation and neural network refinement. Validating antibody specificity remains essential, given structural similarities among pentraxin family members. Overall, NPTXR antibodies serve as indispensable reagents for advancing synaptic biology and related therapeutic research.
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