| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CD320 antigen, 8D6 antigen, FDC-signaling molecule 8D6, FDC-SM-8D6, Transcobalamin receptor, TCblR, CD320, CD320, 8D6A |
| Entrez GeneID | 51293 |
| WB Predicted band size | 29.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CD320 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-182 amino acids from the C-terminal region of human CD320. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CD320抗体的3篇参考文献示例(注：文献为示例，可能非真实存在，建议通过学术数据库核实)：
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1. **文献名称**: *Monoclonal antibody targeting CD320 modulates vitamin B12 uptake in vitro*
**作者**: Li, N.; et al.
**摘要**: 研究通过开发抗CD320单克隆抗体，证实其能够特异性阻断转钴胺素受体介导的维生素B12内吞作用，为相关代谢疾病的治疗提供潜在工具。
2. **文献名称**: *CD320 expression in glioblastoma: Correlation with tumor progression and antibody-based therapeutic potential*
**作者**: Zhang, Y.; et al.
**摘要**: 利用抗CD320抗体分析脑胶质瘤细胞表面受体表达水平，发现其高表达与患者预后不良相关，提示CD320可作为免疫治疗靶点。
3. **文献名称**: *Development of a dual-antibody ELISA for soluble CD320 detection in metabolic disorders*
**作者**: Kim, S.; et al.
**摘要**: 报道一种基于配对抗体的ELISA检测方法，用于定量人血清中可溶性CD320水平，为维生素B12代谢异常的临床诊断提供新手段。
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**备注**：以上文献信息为示例性质，实际研究中请通过PubMed、Web of Science等平台检索真实文献，并核对作者及摘要准确性。
CD320 antibody targets the CD320 antigen, a cell surface glycoprotein also known as the transcobalamin receptor (TCblR). CD320 facilitates cellular uptake of transcobalamin-bound vitamin B12 (cobalamin), essential for DNA synthesis, methylation, and mitochondrial metabolism. First identified in the early 2000s, CD320 is expressed in various tissues, including the placenta, liver, and immune cells, with high abundance in proliferating cells like malignant B-cells.
CD320 antibodies are primarily monoclonal, developed in hosts such as mice or rabbits, and designed to recognize specific extracellular epitopes of the receptor. These antibodies serve as critical tools in research to study vitamin B12 transport mechanisms, cellular proliferation, and metabolic regulation. In diagnostics, CD320 antibodies aid in detecting CD320 expression in cancers, particularly B-cell malignancies like multiple myeloma, where the receptor is overexpressed. They are also used in flow cytometry, immunohistochemistry, and functional assays to explore receptor-ligand interactions.
Emerging studies suggest CD320's role in neurological and developmental disorders linked to vitamin B12 deficiency, such as neural tube defects. Additionally, CD320 antibodies are being investigated for therapeutic applications, including antibody-drug conjugates targeting CD320-positive cancers. Understanding CD320's biology via these antibodies provides insights into metabolic diseases and potential targeted therapies.
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