| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RalBP1-associated Eps domain-containing protein 2, Partner of RalBP1, RalBP1-interacting protein 2, REPS2, POB1 |
| Entrez GeneID | 9185 |
| WB Predicted band size | 71.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This REPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-182 amino acids from the N-terminal region of human REPS2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于REPS2 (N-term)抗体的3篇参考文献的简要列举(注：内容基于模拟文献，建议进一步核实实际研究)：
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1. **文献名称**: *"REPS2 regulates neuronal development via interactions with Eph receptors"*
**作者**: Yamamoto, K., et al.
**摘要**: 该研究通过使用REPS2 N端特异性抗体，揭示了REPS2蛋白在神经元突触形成中的作用。抗体用于免疫共沉淀实验，证实REPS2与Eph受体B2的结合，并发现其缺失影响轴突导向。
2. **文献名称**: *"Development of a polyclonal antibody targeting the N-terminal domain of REPS2 and its application in gastric cancer"*
**作者**: Li, X., et al.
**摘要**: 研究团队开发了一种针对REPS2 N端的兔源多克隆抗体，验证了其在高通量Western blot和免疫组化中的特异性。结果显示，REPS2在胃癌组织中表达显著下调，提示其潜在的肿瘤抑制功能。
3. **文献名称**: *"REPS2 modulates EGFR trafficking and signaling through endosomal complexes"*
**作者**: Martinez, R., et al.
**摘要**: 利用REPS2 N端抗体进行免疫荧光染色，发现REPS2通过调控EGFR内吞过程影响下游MAPK信号通路。研究强调了REPS2在细胞膜受体动态平衡中的关键作用。
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**备注**：以上文献为示例性内容，实际研究中建议通过PubMed或Web of Science以关键词“REPS2 antibody N-terminal”检索最新及权威文献。
The REPS2 (N-term) antibody is designed to target the N-terminal region of the REPS2 protein (RALBP1-associated Eps domain-containing protein 2), encoded by the *REPS2* gene in humans. REPS2 belongs to the REPS (RALBP1-associated Eps domain-containing) family, which interacts with Ral-binding protein 1 (RALBP1) and is implicated in regulating endocytic trafficking, receptor tyrosine kinase signaling, and cytoskeletal dynamics. The protein contains multiple functional domains, including EH (Eps15 homology) domains that mediate protein-protein interactions, particularly in pathways involving Eph receptors, Ral GTPases, and the Ras-MAPK cascade. REPS2 is expressed in various tissues, with notable roles in neuronal development, cell adhesion, and cancer progression, where it may influence metastasis or drug resistance.
The REPS2 (N-term) antibody is commonly used in research applications like Western blotting, immunofluorescence, and immunoprecipitation to detect endogenous REPS2 protein levels. Its specificity for the N-terminal region ensures recognition of full-length REPS2 isoforms while avoiding cross-reactivity with truncated variants or related family members like REPS1. Validation typically includes testing in cell lines or tissues with confirmed REPS2 expression and knockout controls to confirm signal specificity. Dysregulation of REPS2 has been linked to neurological disorders and cancers, making this antibody a valuable tool for studying its molecular functions, interactions, and potential therapeutic relevance. Researchers often utilize it to explore REPS2's involvement in cellular signaling networks or disease mechanisms.
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