| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Adenylosuccinate synthetase isozyme 2 {ECO:0000255|HAMAP-Rule:MF_03127}, AMPSase 2 {ECO:0000255|HAMAP-Rule:MF_03127}, AdSS 2 {ECO:0000255|HAMAP-Rule:MF_03127}, 6344 {ECO:0000255|HAMAP-Rule:MF_03127}, Adenylosuccinate synthetase, acidic isozyme {ECO:0000255|HAMAP-Rule:MF_03127}, Adenylosuccinate synthetase, liver isozyme {ECO:0000255|HAMAP-Rule:MF_03127}, L-type adenylosuccinate synthetase {ECO:0000255|HAMAP-Rule:MF_03127}, IMP--aspartate ligase 2 {ECO:0000255|HAMAP-Rule:MF_03127}, ADSS {ECO:0000255|HAMAP-Rule:MF_03127} |
| Entrez GeneID | 159 |
| WB Predicted band size | 50.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ADSS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-422 amino acids from the C-terminal region of human ADSS. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ADSS(腺苷酸琥珀酸合成酶)抗体的3篇示例参考文献(内容为虚构，仅作格式参考)：
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1. **标题**: *Autoantibodies against Adenylosuccinate Synthase in Systemic Autoimmune Diseases*
**作者**: Smith J, et al.
**摘要**: 研究报道了在系统性红斑狼疮(SLE)患者血清中检测到针对ADSS的自身抗体，提示ADSS可能作为新型自身抗原参与自身免疫反应的分子机制，并可能与疾病活动度相关。
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2. **标题**: *ADSS Antibody Development for Cancer Biomarker Discovery*
**作者**: Lee H, et al.
**摘要**: 通过制备高特异性ADSS单克隆抗体，研究团队发现ADSS在结直肠癌组织中显著高表达，表明其可能作为肿瘤代谢重编程的生物标志物及潜在治疗靶点。
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3. **标题**: *Structural Characterization of ADSS Using Polyclonal Antibodies*
**作者**: Zhang Y, et al.
**摘要**: 利用兔源多克隆抗体结合免疫印迹和免疫共沉淀技术，解析了ADSS蛋白在哺乳动物细胞中的亚细胞定位及与嘌呤代谢通路其他蛋白的相互作用。
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4. **标题**: *ADSS Antibody Cross-Reactivity in Metabolic Disorders*
**作者**: Garcia R, et al.
**摘要**: 研究揭示了ADSS抗体在先天性代谢缺陷患者中的交叉反应性，提示其可能用于检测ADSS功能异常导致的腺苷酸代谢紊乱相关疾病。
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注：以上文献为模拟示例，实际研究中需查询真实数据库(如PubMed)。如需真实文献，建议通过关键词“ADSS antibody”或“Adenylosuccinate Synthase autoantibody”检索相关数据库。
ADSS (Adenylosuccinate Synthase) antibodies are essential tools in studying the enzyme's role in cellular metabolism. ADSS catalyzes the formation of adenylosuccinate from inosine monophosphate (IMP) and aspartate, a critical step in the *de novo* purine biosynthesis pathway. This enzyme exists in two isoforms: ADSS1 (muscle-specific) and ADSS2 (ubiquitously expressed), both vital for ATP and nucleic acid production. Dysregulation of ADSS activity has been linked to metabolic disorders, mitochondrial dysfunction, and certain cancers, driving research interest in its molecular mechanisms.
Antibodies targeting ADSS enable detection and quantification of the enzyme in tissues and cell lines using techniques like Western blotting, immunohistochemistry, and immunofluorescence. They help investigate tissue-specific expression patterns—ADSS1 in cardiac/skeletal muscle and ADSS2 in liver/kidney—and its alteration under pathological conditions. Recent studies also explore ADSS's potential as a biomarker or therapeutic target, particularly in cancers with aberrant purine metabolism. Commercial ADSS antibodies are typically validated for specificity against recombinant or endogenous proteins, though isoform cross-reactivity remains a consideration. These reagents continue to support advances in understanding cellular energy regulation and disease-associated metabolic reprogramming.
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