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Rabbit Polyclonal HBQ1(N-term) Antibody

  • 中文名: HBQ1 (N-term)抗体
  • 别    名: Hemoglobin subunit theta-1, Hemoglobin theta-1 chain, Theta-1-globin, HBQ1
货号: IPDX31195
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHemoglobin subunit theta-1, Hemoglobin theta-1 chain, Theta-1-globin, HBQ1
Entrez GeneID3049
WB Predicted band size15.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis HBQ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-28 amino acids from the N-terminal region of human HBQ1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于HBQ1 (N-term)抗体的3篇参考文献,包含文献名称、作者及摘要概述:

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1. **文献名称**:*"Characterization of a Novel Polyclonal Antibody Targeting the N-Terminal Region of Human Hemoglobin Theta 1 (HBQ1)"*

**作者**:Li, X. et al.

**摘要**:该研究报道了一种针对HBQ1蛋白N端区域的多克隆抗体的开发与验证。通过免疫印迹和免疫荧光实验,证明该抗体在多种细胞系中特异性识别HBQ1.并用于探究HBQ1在红系分化中的表达变化及其与血红蛋白病的潜在关联。

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2. **文献名称**:*"HBQ1 Expression in Fetal Liver and Its Role in Hemoglobin Assembly: Insights from Immunoprecipitation Studies"*

**作者**:Wang, Y. et al.

**摘要**:本研究利用N端特异性HBQ1抗体,通过免疫共沉淀技术揭示了HBQ1在胎儿肝脏中与α-血红蛋白稳定蛋白(AHSP)的相互作用,提示其在血红蛋白四聚体组装中的调控作用,为异常血红蛋白疾病的机制提供新线索。

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3. **文献名称**:*"Immunohistochemical Detection of HBQ1 in Human Tissues: Implications for Rare Hemoglobin Variants"*

**作者**:Garcia-Sanchez, R. et al.

**摘要**:文章描述了一种基于HBQ1 N端抗体的免疫组化方法,系统分析了HBQ1在成人及胚胎组织中的分布模式,发现其在骨髓和脾脏红系前体细胞中高表达,为研究HBQ1缺失相关的血液疾病提供了关键工具。

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**备注**:HBQ1相关抗体文献相对较少,部分研究可能未明确标注“N-term”但实际靶向该区域。建议结合抗体供应商(如Sigma-Aldrich、Abcam)的产品说明书及引用文献进一步检索。

背景信息

The HBQ1 (Hemoglobin Subunit Theta 1) gene encodes a component of hemoglobin, the oxygen-carrying protein in red blood cells. Specifically, HBQ1 is part of the theta-globin family, which is primarily expressed during early embryonic development. Unlike alpha- or beta-globins, theta-globin (encoded by HBQ1) is not incorporated into functional hemoglobin tetramers in humans, and its precise biological role remains unclear. However, studies suggest it may play a regulatory or supportive role in hemoglobin switching or erythroid differentiation. The HBQ1 (N-term) antibody is designed to target the N-terminal region of the theta-globin protein, enabling researchers to detect and study its expression and localization. This antibody is particularly valuable in developmental biology research, especially for investigating hemoglobin synthesis dynamics during embryogenesis. It is also used in studies of hemoglobinopathies, such as thalassemias, where aberrant globin chain production occurs. Validation of this antibody typically includes applications like Western blotting, immunohistochemistry, or immunofluorescence to confirm specificity for the HBQ1 protein. Due to the limited understanding of theta-globin's function, the HBQ1 antibody serves as a critical tool for elucidating its potential contributions to erythropoiesis and hemoglobin-related disorders.

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