| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Galactose-3-O-sulfotransferase 4, Gal3ST-4, 282-, Beta-galactose-3-O-sulfotransferase 4, Gal-beta-1,3-GalNAc 3'-sulfotransferase, GAL3ST4 |
| Entrez GeneID | 79690 |
| WB Predicted band size | 54.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GAL3ST4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from the Central region of human GAL3ST4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GAL3ST4抗体的3篇文献示例(内容基于研究领域常见主题，非真实文献)：
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1. **文献名称**：GAL3ST4 overexpression promotes colorectal cancer metastasis and is associated with poor prognosis
**作者**：Li Y, et al.
**摘要**：该研究通过免疫组化(使用GAL3ST4特异性抗体)发现GAL3ST4在结直肠癌组织中高表达，并与淋巴结转移和患者生存率降低相关。实验表明GAL3ST4通过调控硫酸乙酰肝素修饰促进肿瘤细胞侵袭。
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2. **文献名称**：Role of GAL3ST4 in glioma progression: Insights from antibody-based protein localization
**作者**：Wang X, et al.
**摘要**：利用GAL3ST4抗体进行免疫荧光染色，发现该酶在胶质瘤细胞的细胞膜和胞质中富集。研究证实GAL3ST4通过激活Wnt/β-catenin通路驱动肿瘤增殖，抗体阻断实验可部分抑制肿瘤生长。
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3. **文献名称**：Development of a novel monoclonal antibody against GAL3ST4 for pancreatic cancer biomarker discovery
**作者**：Tanaka K, et al.
**摘要**：研究团队开发了一种高特异性抗GAL3ST4单克隆抗体，并通过ELISA和Western blot验证其灵敏度。该抗体成功用于胰腺癌患者血清样本检测，显示GAL3ST4水平与肿瘤分期正相关。
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(注：以上为模拟文献，实际研究中请通过PubMed或Web of Science检索真实论文。)
The GAL3ST4 antibody is a research tool designed to detect and study the enzyme galactose-3-O-sulfotransferase 4 (GAL3ST4), a member of the sulfotransferase family. This enzyme catalyzes the transfer of sulfate groups to specific galactose residues in glycoproteins and glycolipids, modifying their structure and function. GAL3ST4 is implicated in sulfation processes that influence cell-cell interactions, immune responses, and extracellular matrix remodeling. Its expression has been linked to certain cancers, including gliomas and colorectal carcinomas, where it may contribute to tumor progression by altering cell adhesion or promoting angiogenesis.
The GAL3ST4 antibody is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to visualize protein expression patterns in tissues or cell lines. Researchers utilize it to explore GAL3ST4's role in disease mechanisms, particularly its involvement in cancer biology and potential as a diagnostic or prognostic biomarker. Recent studies also suggest associations with neurological disorders, though its precise physiological and pathological functions remain under investigation.
Available as polyclonal or monoclonal formats, the antibody’s specificity and sensitivity depend on epitope selection and validation. Proper controls are essential to ensure accurate detection, given the structural similarities among sulfotransferase family members. Ongoing research aims to clarify GAL3ST4's interactions with substrates and its therapeutic potential as a target for small-molecule inhibitors or antibody-based therapies.
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