| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Voltage-dependent calcium channel gamma-4 subunit, Neuronal voltage-gated calcium channel gamma-4 subunit, Transmembrane AMPAR regulatory protein gamma-4, TARP gamma-4, CACNG4 |
| Entrez GeneID | 27092 |
| WB Predicted band size | 36.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CACNG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the Central region of human CACNG4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CACNG4抗体的3篇参考文献示例(注：以下内容为示例性概括，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*"Selective targeting of CACNG4 isoforms by a novel antibody modulates AMPA receptor function"*
**作者**：Li, X., et al.
**摘要**：研究报道了一种新型CACNG4特异性抗体的开发，该抗体可识别不同剪接异构体。通过免疫沉淀和免疫荧光验证，发现其能抑制CACNG4与AMPA受体的相互作用，影响突触传递效率。
2. **文献名称**：*"CACNG4 antibody-based profiling reveals differential expression in glioblastoma subtypes"*
**作者**：Wang, Y., et al.
**摘要**：利用CACNG4单克隆抗体对胶质母细胞瘤组织进行免疫组化分析，发现CACNG4在特定分子亚型中显著高表达，提示其作为潜在生物标志物的价值。
3. **文献名称**：*"Validation of a polyclonal CACNG4 antibody for detecting calcium channel γ4 subunit in rodent brain"*
**作者**：Smith, J.R., et al.
**摘要**：研究验证了一种多克隆抗体的特异性，通过Western blot和免疫染色证实CACNG4在小鼠皮层和海马神经元中富集，并参与钙通道调控。
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建议通过PubMed或Google Scholar以关键词“CACNG4 antibody”或“CACNG4 immunohistochemistry”检索最新文献获取准确信息。
The CACNG4 antibody is a tool used to detect the CACNG4 protein, a member of the calcium channel gamma subunit family. CACNG4. encoded by the *CACNG4* gene, is a transmembrane protein that modulates the trafficking and biophysical properties of voltage-gated calcium channels (VGCCs), particularly in the central nervous system. As an auxiliary subunit, it interacts with pore-forming α1 subunits of VGCCs to regulate calcium influx, influencing neuronal excitability, synaptic plasticity, and neurotransmitter release.
CACNG4 is implicated in neurological disorders, including epilepsy and neuropsychiatric conditions, due to its role in maintaining calcium homeostasis and synaptic function. Antibodies targeting CACNG4 are essential for studying its expression patterns, cellular localization, and interactions in tissues, often via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Research using these antibodies has revealed altered CACNG4 expression in disease models, suggesting its potential as a biomarker or therapeutic target. However, specificity and validation remain critical, as cross-reactivity with other gamma subunits (e.g., CACNG2. CACNG8) can occur. Overall, CACNG4 antibodies contribute to unraveling the protein's physiological and pathological roles in calcium signaling and neural networks.
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