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Rabbit Polyclonal YIPF1(N-term) Antibody

  • 中文名: YIPF1 (N-term)抗体
  • 别    名: Protein YIPF1, YIP1 family member 1, YIPF1
货号: IPDX31180
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein YIPF1, YIP1 family member 1, YIPF1
Entrez GeneID54432
WB Predicted band size34.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis YIPF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-63 amino acids from the N-terminal region of human YIPF1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于YIPF1 (N-term)抗体的3篇参考文献的简要总结(注:以下内容为模拟示例,实际文献需通过学术数据库查询确认):

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1. **文献名称**:*YIPF1 regulates Golgi structure and extracellular matrix secretion in fibroblasts*

**作者**:Smith A, et al.

**摘要**:本研究利用YIPF1 (N-term)特异性抗体,通过免疫荧光和Western blot技术,揭示了YIPF1蛋白在高尔基体膜结构维持中的作用,并发现其缺失会导致胶原蛋白分泌异常,影响细胞外基质稳态。

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2. **文献名称**:*A novel role of YIPF1 in ER-to-Golgi transport revealed by CRISPR screening*

**作者**:Chen L, et al.

**摘要**:作者通过CRISPR筛选结合YIPF1 (N-term)抗体的免疫沉淀分析,发现YIPF1与COPII囊泡组分相互作用,调控内质网到高尔基体的货物运输,为分泌通路机制提供了新见解。

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3. **文献名称**:*Dysregulation of YIPF1 in neurodegenerative diseases: Evidence from human brain tissue analysis*

**作者**:Wang Y, et al.

**摘要**:该研究使用YIPF1 (N-term)抗体对阿尔茨海默病患者脑组织进行免疫组化分析,发现YIPF1表达水平与tau蛋白异常聚集呈负相关,提示其可能参与神经退行性疾病的病理过程。

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如需具体文献,建议在PubMed或Google Scholar中检索关键词“YIPF1 antibody N-terminal”或“YIPF1 N-term”,并筛选实验方法中明确使用该抗体的研究。

背景信息

The YIPF1 (N-term) antibody is a targeted immunological tool designed to recognize the N-terminal region of the YIPF1 protein, a member of the Yip1 domain family. YIPF1 (Yip1-interacting factor homolog 1) is a conserved transmembrane protein implicated in intracellular vesicular transport, particularly in Golgi-related processes and endoplasmic reticulum (ER)-to-Golgi trafficking. It plays roles in maintaining Golgi structure, regulating protein secretion, and facilitating cargo sorting. Dysregulation of YIPF1 has been linked to diseases such as cancer and neurodegenerative disorders. The antibody is commonly used in techniques like Western blotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to study YIPF1 expression, localization, and interactions in cellular models or tissue samples. Its specificity for the N-terminal domain allows researchers to distinguish YIPF1 from related family members (e.g., YIPF2-YIPF7) and investigate post-translational modifications or functional domains. Validated applications often include exploring YIPF1's involvement in secretory pathways, autophagy, or disease mechanisms. Commercial versions are typically raised in rabbits or mice, with validation data including knockout cell line controls. Researchers utilize this tool to advance understanding of membrane trafficking networks and their pathophysiological implications.

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