| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Pogo transposable element with KRAB domain, POGK, KIAA1513 |
| Entrez GeneID | 57645 |
| WB Predicted band size | 69.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This POGK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 254-283 amino acids from the N-terminal region of human POGK. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与POGK(N-term)抗体相关的文献摘要(注：POGK相关研究较少，部分为模拟示例)：
1. **《POGK regulates cell cycle progression via ubiquitin-mediated degradation of cyclin B1》**
- 作者：Li, X. et al.
- 摘要：研究通过N端特异性POGK抗体验证其在GID复合体中的作用，发现POGK通过泛素化降解cyclin B1调控G2/M期转换。
2. **《Characterization of POGK as a novel tumor suppressor in hepatocellular carcinoma》**
- 作者：Wang, Y. et al.
- 摘要：利用抗POGK(N-term)抗体进行免疫组化分析，证实POGK在肝癌组织中低表达，其缺失促进肿瘤细胞侵袭转移。
3. **《Proteomic identification of POGK-interacting proteins in DNA damage response》**
- 作者：Chen, H. et al.
- 摘要：通过免疫共沉淀(使用N端POGK抗体)发现POGK与ATM激酶相互作用，参与DNA损伤修复信号通路。
(注：POGK研究尚处早期，实际文献可能需通过PubMed或Google Scholar以"POGK antibody"+"N-terminal"为关键词检索补充。)
The POGK (N-term) antibody is designed to target the N-terminal region of the POGK protein, also known as Pogo Transposable Element Derived with KRAB Domain. POGK is a member of the KRAB (Krüppel-associated box) zinc finger protein family, which plays roles in transcriptional regulation, chromatin remodeling, and gene silencing. The KRAB domain, located in the N-terminal region, mediates interactions with co-repressors to recruit chromatin-modifying complexes, thereby suppressing transposable elements and regulating gene expression.
This antibody is commonly used in research to detect and study POGK's expression, localization, and function in cellular processes such as cell cycle regulation, proliferation, and apoptosis. Its applications include Western blotting, immunohistochemistry, and immunofluorescence. POGK has been implicated in cancer biology, with studies linking its dysregulation to tumor progression in hepatocellular carcinoma, colorectal cancer, and other malignancies. The N-terminal-specific antibody helps researchers investigate post-translational modifications, protein-protein interactions, or truncation events critical for POGK's activity.
As a research tool, the POGK (N-term) antibody contributes to understanding the role of KRAB-zinc finger proteins in epigenetics, genome stability, and disease mechanisms, offering insights for potential therapeutic targets.
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