| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Inactive gamma-glutamyltranspeptidase 2, GGT 2, Gamma-glutamyltransferase 2, Glutathione hydrolase 2, GGT2 |
| WB Predicted band size | 61.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GGT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human GGT2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GGT2 (N-term)抗体的3篇参考文献示例(部分信息为模拟虚构，仅供参考)：
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1. **文献名称**：*Characterization of a Novel N-terminal Specific Antibody for Gamma-Glutamyltransferase 2 (GGT2) in Human Tissues*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种针对GGT2蛋白N端表位的特异性抗体，验证了其在人肝脏和肾脏组织中的表达定位，并证实其与氧化应激调控的相关性。
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2. **文献名称**：*GGT2 Isoform-Specific Antibody Reveals Distinct Subcellular Localization and Function in Cancer Cells*
**作者**：Li X, et al.
**摘要**：通过N端抗体分析发现，GGT2在多种癌细胞中定位于线粒体膜，可能通过调控谷胱甘肽代谢促进肿瘤耐药性，与GGT1功能存在显著差异。
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3. **文献名称**：*Development and Application of an N-terminal GGT2 Antibody for Neurological Disease Biomarker Detection*
**作者**：Wang Y, et al.
**摘要**：该研究利用GGT2的N端抗体检测脑脊液中的GGT2水平，发现其与神经退行性疾病(如阿尔茨海默病)的病程进展呈正相关。
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如需真实文献，建议通过PubMed或Google Scholar以“GGT2 antibody N-terminal”为关键词检索，并筛选功能验证或应用类研究。
**Background of GGT2 (N-term) Antibody**
Gamma-glutamyltransferase 2 (GGT2), also known as gamma-glutamyl transpeptidase 2. is a membrane-bound enzyme involved in glutathione metabolism and the regulation of cellular redox homeostasis. It catalyzes the hydrolysis of extracellular glutathione and transfers gamma-glutamyl moieties to acceptor molecules, playing a critical role in amino acid transport, detoxification, and inflammatory responses. GGT2 is one of two paralogs (GGT1 and GGT2) in humans, with distinct tissue expression patterns. While GGT1 is widely expressed, GGT2 is primarily found in the liver, kidney, and brain, and is implicated in diseases such as liver fibrosis, neurodegenerative disorders, and cancers.
The GGT2 (N-term) antibody is a selective immunological tool targeting the N-terminal region of the GGT2 protein. This region is critical for enzymatic activity and protein-protein interactions. Researchers utilize this antibody to study GGT2 expression, localization, and function in various biological contexts, including oxidative stress, drug metabolism, and disease progression. Its specificity is validated through techniques like Western blotting, immunohistochemistry, and immunofluorescence, often in comparison with GGT1 to distinguish paralog-specific roles.
Development of this antibody supports ongoing research into GGT2's pathophysiological roles, particularly its potential as a biomarker or therapeutic target in liver diseases and malignancies. Its application enhances understanding of glutathione-dependent pathways and their impact on cellular resilience and disease mechanisms.
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