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Rabbit Polyclonal MATN1 Antibody

  • 中文名: MATN1抗体
  • 别    名: Cartilage matrix protein, Matrilin-1, MATN1, CMP, CRTM
货号: IPDX31170
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCartilage matrix protein, Matrilin-1, MATN1, CMP, CRTM
Entrez GeneID4146
WB Predicted band size53.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis MATN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376-405 amino acids from the C-terminal region of human MATN1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于MATN1抗体的3篇参考文献示例,涵盖其在疾病机制、诊断及基础研究中的应用:

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1. **文献名称**:*Autoantibodies to Matrilin-1 in Rheumatoid Arthritis Patients: Association with Cartilage Degradation*

**作者**:Müller-Ladner U, et al.

**摘要**:研究发现类风湿性关节炎(RA)患者血清中存在抗MATN1的自身抗体,其水平与关节软骨破坏程度呈正相关,提示MATN1抗体可能作为RA软骨损伤的生物标志物。

2. **文献名称**:*Matrilin-1-Directed Autoimmunity and Its Role in Osteoarthritis Pathogenesis*

**作者**:Häusler M, et al.

**摘要**:通过体外实验证实,MATN1抗体可结合软骨细胞外基质中的Matrilin-1蛋白,干扰其与胶原网络的相互作用,从而促进骨关节炎(OA)的基质降解过程。

3. **文献名称**:*Anti-MATN1 Antibodies as a Novel Diagnostic Tool for Juvenile Idiopathic Arthritis*

**作者**:Smith JJ, et al.

**摘要**:研究评估了抗MATN1抗体在儿童特发性关节炎(JIA)中的诊断价值,发现其特异性高于传统标志物,可能用于早期鉴别JIA亚型。

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**备注**:以上文献为示例性质,实际引用时需核实具体论文是否存在及内容准确性。建议通过PubMed或Web of Science以关键词“MATN1 antibody”、“Matrilin-1 autoantibody”检索最新研究。

背景信息

The MATN1 antibody targets matrilin-1. a cartilage-specific extracellular matrix (ECM) protein encoded by the *MATN1* gene. Matrilin-1 is a member of the matrilin family, which plays a structural role in ECM organization and mediates interactions between collagen fibrils and other ECM components, such as cartilage oligomeric matrix protein (COMP). It is predominantly expressed in developing and adult hyaline cartilage, contributing to skeletal development, chondrocyte differentiation, and tissue resilience. MATN1 antibodies are widely used in research to study cartilage biology, skeletal disorders (e.g., osteoarthritis, chondrodysplasias), and ECM remodeling processes. These antibodies enable the detection of matrilin-1 localization, expression levels, and post-translational modifications via techniques like immunohistochemistry, Western blotting, or immunofluorescence. Studies using MATN1 antibodies have revealed its reduced expression in degenerative cartilage diseases, suggesting its role as a biomarker or therapeutic target. Additionally, they aid in investigating genetic mutations linked to skeletal malformations. Commercial MATN1 antibodies are typically validated for specificity in human, mouse, or rat tissues, supporting both basic and translational research in orthopedics, developmental biology, and connective tissue pathologies.

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