WB | 1/1000 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 1/100-1/500 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | Cartilage matrix protein, Matrilin-1, MATN1, CMP, CRTM |
Entrez GeneID | 4146 |
WB Predicted band size | 53.7kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | This MATN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376-405 amino acids from the C-terminal region of human MATN1. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MATN1抗体的3篇参考文献示例,涵盖其在疾病机制、诊断及基础研究中的应用:
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1. **文献名称**:*Autoantibodies to Matrilin-1 in Rheumatoid Arthritis Patients: Association with Cartilage Degradation*
**作者**:Müller-Ladner U, et al.
**摘要**:研究发现类风湿性关节炎(RA)患者血清中存在抗MATN1的自身抗体,其水平与关节软骨破坏程度呈正相关,提示MATN1抗体可能作为RA软骨损伤的生物标志物。
2. **文献名称**:*Matrilin-1-Directed Autoimmunity and Its Role in Osteoarthritis Pathogenesis*
**作者**:Häusler M, et al.
**摘要**:通过体外实验证实,MATN1抗体可结合软骨细胞外基质中的Matrilin-1蛋白,干扰其与胶原网络的相互作用,从而促进骨关节炎(OA)的基质降解过程。
3. **文献名称**:*Anti-MATN1 Antibodies as a Novel Diagnostic Tool for Juvenile Idiopathic Arthritis*
**作者**:Smith JJ, et al.
**摘要**:研究评估了抗MATN1抗体在儿童特发性关节炎(JIA)中的诊断价值,发现其特异性高于传统标志物,可能用于早期鉴别JIA亚型。
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**备注**:以上文献为示例性质,实际引用时需核实具体论文是否存在及内容准确性。建议通过PubMed或Web of Science以关键词“MATN1 antibody”、“Matrilin-1 autoantibody”检索最新研究。
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