| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Kinetochore-associated protein DSN1 homolog, DSN1, C20orf172, MIS13 |
| Entrez GeneID | 79980 |
| WB Predicted band size | 40.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This DSN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-286 amino acids from the C-terminal region of human DSN1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DSN1抗体的3篇参考文献的简要信息：
1. **文献名称**：*"DSN1作为有丝分裂检查点调控因子的功能研究"*
**作者**：Suzuki A, et al.
**摘要**：本研究利用特异性DSN1抗体，通过免疫荧光和Western blot技术，揭示了DSN1在维持染色体正确分离中的关键作用。实验表明，DSN1抗体可有效干扰MIS12复合体的组装，导致有丝分裂错误和细胞周期停滞。
2. **文献名称**：*"DSN1在乳腺癌中的表达及其临床意义"*
**作者**：Wang L, et al.
**摘要**：通过免疫组化(IHC)分析乳腺癌组织样本，作者使用DSN1抗体检测其蛋白表达水平，发现DSN1过表达与肿瘤恶性程度及患者预后不良显著相关，提示其可能作为潜在的诊断标志物。
3. **文献名称**：*"靶向DSN1的抗体开发及其在抗癌药物筛选中的应用"*
**作者**：Chen R, et al.
**摘要**：该研究报道了一种新型DSN1单克隆抗体的制备与验证，证实其高特异性和灵敏度。通过体外实验，该抗体成功用于筛选抑制DSN1功能的小分子化合物，为靶向治疗提供了实验工具。
(注：以上文献信息为模拟示例，实际引用时需以真实发表的论文为准。)
The DSN1 antibody targets the DSN1 protein, a critical component of the Ska complex (Spindle and Kinetochore-Associated complex) in eukaryotic cells. DSN1 (DASH kinetochore complex component 1) is essential for accurate chromosome segregation during mitosis and meiosis. It interacts with other Ska subunits (Ska1. Ska2. Ska3) to stabilize kinetochore-microtubule attachments, ensuring proper spindle assembly and chromosome movement. Dysregulation of DSN1 is linked to chromosomal instability, a hallmark of cancer and genetic disorders.
DSN1 antibodies are widely used in research to study cell cycle regulation, mitotic errors, and cancer biology. They enable detection of DSN1 expression via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Studies reveal that DSN1 is overexpressed in various cancers (e.g., colorectal, breast, and liver cancers), correlating with poor prognosis. This makes DSN1 a potential biomarker for cancer diagnosis and a therapeutic target. Antibodies against DSN1 also aid in exploring its structural role in the kinetochore and its interplay with checkpoint proteins like Mad2 and BubR1. Commercial DSN1 antibodies are typically raised in rabbits or mice, validated for specificity and application compatibility. Ongoing research focuses on elucidating DSN1's post-translational modifications and its role in drug resistance, expanding its relevance in both basic and clinical contexts.
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