| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | COP9 signalosome complex subunit 7a, SGN7a, Signalosome subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a, COPS7A, CSN7A, DERP10 |
| Entrez GeneID | 50813 |
| WB Predicted band size | 30.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This COPS7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the C-terminal region of human COPS7A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与COPS7A抗体相关的文献摘要信息(文献为虚构示例，供参考)：
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1. **文献名称**: *"Characterization of COPS7A in the COP9 Signalosome Complex"*
**作者**: Smith J, et al. (2020)
**摘要**: 本研究利用特异性COPS7A抗体，通过免疫沉淀和质谱分析验证了其在COP9信号复合体中的相互作用网络，揭示了COPS7A在泛素-蛋白酶体通路调控中的作用。
2. **文献名称**: *"COPS7A Antibody Validation for Immunohistochemical Staining in Cancer Tissues"*
**作者**: Lee H, et al. (2018)
**摘要**: 文章验证了一种高亲和力COPS7A多克隆抗体的特异性，证明其可用于乳腺癌组织样本的免疫组化检测，并发现COPS7A表达与患者预后相关。
3. **文献名称**: *"Functional Analysis of COPS7A Knockout Models Using CRISPR/Cas9"*
**作者**: Garcia R, et al. (2021)
**摘要**: 通过Western Blot和免疫荧光技术，使用COPS7A抗体确认基因敲除效率，发现COPS7A缺失导致胚胎发育异常及细胞周期紊乱。
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**注意**：以上文献为示例性内容，实际研究中建议通过PubMed或Google Scholar以关键词“COPS7A antibody”或“COP9 signalosome subunit 7A”检索真实文献。
The COPS7A antibody targets the COP9 signalosome subunit 7A (COPS7A), a critical component of the COP9 signalosome (CSN) complex. The CSN is an evolutionarily conserved, multi-subunit protein complex involved in regulating ubiquitin-proteasome-mediated protein degradation, primarily by modulating cullin-RING ubiquitin ligases (CRLs). COPS7A, also known as CSN7A, contributes to the structural stability of the CSN complex and participates in its enzymatic activity, including deneddylation (removal of NEDD8 from cullins) and deubiquitination. This regulatory function impacts diverse cellular processes such as cell cycle progression, DNA damage response, and signal transduction.
Antibodies against COPS7A are widely used in biomedical research to study CSN complex assembly, dynamics, and its role in disease. They enable detection of COPS7A expression levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of COPS7A and the CSN complex has been implicated in cancer, neurodegenerative disorders, and autoimmune diseases, as altered protein degradation pathways can drive genomic instability or aberrant cell proliferation. Research utilizing COPS7A antibodies has particularly highlighted its tumor-suppressive or oncogenic dual roles, depending on cellular context. Additionally, studies in model organisms underscore its importance in development and stress adaptation. These tools remain vital for elucidating CSN-mediated regulatory networks in health and disease.
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