| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cathepsin O, CTSO, CTSO1 |
| Entrez GeneID | 1519 |
| WB Predicted band size | 36.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CTSO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-98 amino acids from the N-terminal region of human CTSO. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CTSO(N-term)抗体的模拟参考文献示例(请注意，这些为虚构内容，实际文献需通过学术数据库检索)：
1. **文献名称**: "Development and Characterization of a Novel CTSO (N-terminal) Monoclonal Antibody for Cancer Biomarker Studies"
**作者**: Zhang L, et al.
**摘要**: 本研究报道了一种针对CTSO蛋白N端表位的高特异性单克隆抗体的开发。该抗体通过ELISA和Western blot验证，能够特异性识别重组CTSO，并在乳腺癌组织样本中检测到CTSO的异常表达，提示其作为肿瘤标志物的潜力。
2. **文献名称**: "Structural Insights into CTSO Protease Function Using N-terminal Specific Antibodies"
**作者**: Gupta R, et al.
**摘要**: 通过结合X射线晶体学与抗CTSO N端抗体，本文揭示了CTSO蛋白酶的活性结构域构象变化。抗体的应用证实了N端区域在底物结合中的关键作用，为设计CTSO抑制剂提供了结构基础。
3. **文献名称**: "CTSO (N-term) Antibody-Based Detection of Osteoclast Activity in Bone Remodeling Disorders"
**作者**: Tanaka K, et al.
**摘要**: 研究利用抗CTSO N端多克隆抗体，建立了骨组织中CTSO活性的免疫组化检测方法。结果显示，在骨质疏松模型中CTSO表达显著上调，表明其参与破骨细胞介导的骨吸收过程。
4. **文献名称**: "Cross-reactivity Analysis of Commercial CTSO Antibodies: Implications for Neurodegenerative Disease Research"
**作者**: Müller S, et al.
**摘要**: 本研究评估了多种市售CTSO抗体(包括N端抗体)的特异性，发现部分抗体存在与非靶蛋白的交叉反应。作者优化了实验条件，为阿尔茨海默病中CTSO与淀粉样蛋白相互作用的可靠检测提供了改进方案。
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**提示**：实际文献建议通过以下途径检索：
- 在PubMed或Google Scholar搜索关键词：`"CTSO antibody" AND "N-terminal"`
- 限定文献类型(如研究论文、综述)及发表年份。
- 关注抗体开发、蛋白功能或疾病机制相关期刊(如*Scientific Reports*, *mAbs*等)。
CTSO (Cathepsin O), also known as Cathepsin X or Cathepsin Z, is a lysosomal cysteine protease belonging to the papain family. It is encoded by the *CTSO* gene and is involved in protein degradation, antigen processing, and cellular homeostasis. Unlike other cathepsins, CTSO exhibits unique carboxypeptidase activity due to its structural features, enabling selective cleavage of C-terminal residues. It plays roles in immune regulation, neurodevelopment, and tissue remodeling, with dysregulation linked to cancer progression, neurodegenerative disorders, and inflammatory diseases.
The CTSO (N-term) antibody specifically targets the N-terminal region of the CTSO protein, allowing researchers to detect full-length or precursor forms of the enzyme. This antibody is crucial for distinguishing CTSO from homologous proteases, as the N-terminal domain contains sequence variability that ensures specificity. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study CTSO expression, localization, and processing in various tissues. Applications include investigating its role in tumor invasiveness, synaptic plasticity, and lysosomal storage disorders. The antibody's reliability in identifying CTSO contributes to understanding its pathophysiological mechanisms and potential therapeutic targeting.
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