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Rabbit Polyclonal SNRK Antibody

  • 中文名： SNRK抗体
  • 别    名： SNF-related serine/threonine-protein kinase, SNF1-related kinase, SNRK {ECO:0000312|EMBL:AAH715671}
货号: IPDX31153
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesAMS2; MAT 2; MAT 2A; MAT II; Mat2a; MATA2; MATII; SAMS 2; SAMS2;;MAT2A
WB Predicted band sizeCalculated MW: 44 kDa ; Observed MW: 48 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human MAT2A
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇与SNRK抗体相关的文献摘要信息整理(注：文献为示例性概括，非真实存在)：

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1. **文献名称**: "SNRK regulates adipocyte differentiation via AMPK-dependent signaling"

**作者**: Tanaka K, et al.

**摘要**: 本研究使用SNRK特异性抗体证实，SNRK通过磷酸化AMPKα调控脂肪细胞分化，并抑制肥胖相关炎症反应。Western blot和免疫荧光显示SNRK在脂肪前体细胞分化早期高表达。

2. **文献名称**: "Sucrose Nonfermenting-Related Kinase (SNRK) deficiency exacerbates cardiac hypertrophy"

**作者**: Liu Y, et al.

**摘要**: 通过敲除小鼠模型和SNRK抗体检测，发现SNRK缺失加重压力负荷诱导的心肌肥厚，其机制与抑制NF-κB信号通路及减少抗氧化酶表达相关，提示SNRK具有心脏保护作用。

3. **文献名称**: "SNRK suppresses tumor metastasis by modulating EMT markers in breast cancer"

**作者**: Chen R, et al.

**摘要**: 利用SNRK抗体进行组织芯片分析，发现SNRK低表达与乳腺癌患者不良预后相关。体外实验表明SNRK通过稳定E-cadherin抑制上皮-间质转化(EMT)，降低癌细胞侵袭能力。

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注：实际文献需通过PubMed/Google Scholar检索关键词(如"SNRK antibody"、"SNRK function")获取。建议使用以下真实数据库：

- **NCBI PubMed**: https://pubmed.ncbi.nlm.nih.gov

- **Google Scholar**: https://scholar.google.com

背景信息

SNRK (Sucrose Non-fermenting Related Kinase) is a serine/threonine protein kinase belonging to the SNF1/AMPK kinase family, which plays critical roles in cellular energy homeostasis and metabolic regulation. Initially identified through homology with AMP-activated protein kinase (AMPK), SNRK shares structural features such as an N-terminal kinase domain and a C-terminal regulatory region, though its exact functional mechanisms remain less characterized compared to AMPK. Research suggests SNRK is involved in diverse physiological processes, including lipid metabolism, inflammation, and angiogenesis. It is highly expressed in metabolic tissues like adipose tissue, where it regulates adipocyte differentiation and lipolysis, and in endothelial cells, influencing vascular function. Studies link SNRK dysregulation to metabolic disorders (e.g., obesity, diabetes) and cardiovascular diseases, highlighting its potential as a therapeutic target. SNRK-specific antibodies are essential tools for investigating its expression, localization, and activity in biological systems. These antibodies enable detection via Western blotting, immunohistochemistry, and immunofluorescence, aiding research into SNRK's signaling pathways and interactions with partners like 14-3-3 proteins. Recent work also explores SNRK's role in immune responses and cancer progression, underscoring its broad biomedical relevance.

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