| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 1A; GDIL; MRX41; MRX48; OPHN2; XAP-4; RABGD1A; RABGDIA |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human GDI1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于Mouse TLR8抗体的参考文献示例(注：以下内容为模拟生成，仅供参考)：
1. **"Characterization of a Novel Monoclonal Antibody Against Mouse TLR8 for Flow Cytometry Applications"**
*Authors: Smith A, et al.*
摘要：该研究报道了一种新型抗小鼠TLR8单克隆抗体的开发，通过免疫印迹和流式细胞术验证其特异性，证实其可用于检测小鼠巨噬细胞和树突状细胞中的TLR8表达。
2. **"TLR8-Specific Antibody Reveals Differential Expression in Murine Immune Cell Subsets"**
*Authors: Lee J, et al.*
摘要：作者利用自制的抗小鼠TLR8抗体，系统分析了TLR8在小鼠脾脏、淋巴结等组织中的细胞分布，发现其在高表达于特定髓系细胞亚群，并与TLR7表达呈互补模式。
3. **"Functional Blockade of Mouse TLR8 Using a Neutralizing Antibody Modulates Antiviral Responses"**
*Authors: Zhang Y, et al.*
摘要：研究通过中和性抗TLR8抗体证实了TLR8在小鼠RNA病毒识别中的关键作用，抗体处理显著抑制了促炎细胞因子(如IL-12)的产生，提示其作为免疫调节工具的潜力。
4. **"Comparative Analysis of Commercial Anti-TLR8 Antibodies in Murine Models of Autoimmunity"**
*Authors: Müller R, et al.*
摘要：该文献评估了多种市售抗小鼠TLR8抗体的性能，发现部分抗体存在交叉反应性(如与TLR7结合)，并提出标准化验证方案以确保实验结果的可靠性。
注：实际引用时请通过PubMed、Web of Science等平台检索真实文献，使用关键词“mouse TLR8 antibody”“anti-TLR8 monoclonal”等，并核对抗体克隆号及应用场景的匹配性。
Mouse TLR8 (Toll-like receptor 8) antibodies are essential tools for studying innate immune responses in murine models. TLR8. a member of the Toll-like receptor family, recognizes pathogen-associated molecular patterns (PAMPs), particularly single-stranded RNA from viruses, and activates signaling pathways that trigger pro-inflammatory cytokine production. In mice, TLR8 is functionally distinct from human TLR8 due to species-specific variations in ligand recognition and signaling. Research on mouse TLR8 is critical for understanding antiviral immunity, autoimmune diseases, and TLR-mediated therapeutic interventions.
Mouse TLR8 antibodies are designed to detect and quantify endogenous TLR8 protein expression in tissues, immune cells, or cell lines. They enable applications like Western blotting, immunohistochemistry, flow cytometry, and immunofluorescence to study TLR8 localization, expression dynamics, and interaction partners. These antibodies often target specific epitopes, such as extracellular or intracellular domains, to investigate receptor activation or downstream signaling events (e.g., NF-κB or interferon pathways). Validation typically includes testing in TLR8-knockout models to confirm specificity.
High-quality mouse TLR8 antibodies are critical for minimizing cross-reactivity with other TLRs (e.g., TLR7) and ensuring reproducibility. Their use has advanced studies in infectious diseases, cancer immunology, and vaccine development, providing insights into TLR8's role in bridging innate and adaptive immunity.
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