| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Gamma-tubulin complex component 2, GCP-2, hGCP2, Gamma-ring complex protein 103 kDa, h103p, hGrip103, Spindle pole body protein Spc97 homolog, hSpc97, TUBGCP2, GCP2 |
| Entrez GeneID | 10844 |
| WB Predicted band size | 102.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TUBGCP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 394-423 amino acids from the Central region of human TUBGCP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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The TUBGCP2 (Tubulin Gamma Complex Component 2) antibody is a tool used to detect and study the TUBGCP2 protein, a critical subunit of the γ-tubulin ring complex (γ-TuRC). γ-TuRC is essential for microtubule nucleation, a fundamental process in cellular architecture, intracellular transport, and mitosis. TUBGCP2. along with other γ-TuRC components (e.g., TUBGCP3. TUBGCP4), helps anchor γ-tubulin to cellular structures like centrosomes, ensuring proper assembly of microtubules from α/β-tubulin dimers. Dysregulation of γ-TuRC components is linked to mitotic defects, genomic instability, and diseases such as cancer.
The TUBGCP2 antibody is widely employed in cell biology research to investigate microtubule organization, mitotic spindle formation, and centrosome function. It is commonly used in techniques like immunofluorescence, Western blotting, and immunoprecipitation to localize TUBGCP2 within cells, assess its expression levels, or explore protein-protein interactions. Commercial antibodies are typically raised in hosts such as rabbits or mice, targeting specific epitopes within the human TUBGCP2 sequence, though cross-reactivity with orthologs in model organisms (e.g., mice) may vary. Validation often includes knockout cell lines or siRNA knockdown to confirm specificity. Researchers rely on this antibody to unravel mechanisms underlying cell division, developmental disorders, and microtubule-related pathologies.
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