| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | COP9 signalosome complex subunit 1, SGN1, Signalosome subunit 1, G protein pathway suppressor 1, GPS-1, JAB1-containing signalosome subunit 1, Protein MFH, GPS1, COPS1, CSN1 |
| Entrez GeneID | 2873 |
| WB Predicted band size | 55.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This GPS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-170 amino acids from the Central region of human GPS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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GPS1 (G Protein Pathway Suppressor 1), also known as COPS1 or CSN1. is a critical subunit of the COP9 signalosome (CSN), a conserved protein complex involved in regulating ubiquitin-dependent proteolysis. The CSN complex, composed of eight subunits (CSN1–CSN8), plays a central role in modulating cullin-RING ubiquitin ligases (CRLs), which mediate protein degradation via the ubiquitin-proteasome system. GPS1/CSN1 contributes to the structural integrity of the CSN complex and participates in deneddylation, a process that removes NEDD8 post-translational modifications from cullins to regulate CRL activity. This dynamic control impacts diverse cellular processes, including cell cycle progression, DNA repair, and stress responses.
GPS1 is implicated in key signaling pathways, such as NF-κB and JNK, through its interaction with CRLs. Dysregulation of GPS1 expression or function has been linked to pathological conditions, including cancer, neurodegenerative disorders, and immune dysregulation. For instance, reduced GPS1 levels correlate with tumor progression due to altered protein stability of oncogenes or tumor suppressors. In neurodegenerative contexts, defective CSN activity may disrupt protein homeostasis, contributing to aggregation-prone environments.
Antibodies targeting GPS1 are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to explore GPS1's role in cellular pathways and disease mechanisms. These antibodies also aid in evaluating therapeutic strategies aimed at modulating ubiquitin-proteasome activity or CSN-associated pathways.
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