| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Keratin-like protein KRT222, Keratin-222, Keratin-222 pseudogene, KRT222, KA21, KRT222P |
| Entrez GeneID | 125113 |
| WB Predicted band size | 34.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This KRT222P antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-250 amino acids from the C-terminal region of human KRT222P. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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The KRT222P antibody is associated with the study of keratin 222 pseudogene (KRT222P), a member of the keratin family, which plays critical roles in structural integrity and cellular function of epithelial tissues. Keratins are intermediate filament proteins categorized into type I (acidic) and type II (basic), forming heteropolymers essential for cell mechanical stability, signaling, and stress response. While KRT222P is annotated as a pseudogene due to sequence variations that likely render it non-functional, its retained homology to functional keratins suggests potential regulatory roles or transcriptional activity in specific contexts.
Antibodies targeting KRT222P are primarily utilized in research to investigate its expression patterns, evolutionary significance, and possible involvement in diseases. Though direct functional data on KRT222P remains limited, studies on pseudogenes highlight their roles in modulating mRNA stability, acting as competing endogenous RNAs (ceRNAs), or influencing chromatin remodeling. Dysregulation of keratin pseudogenes has been implicated in cancers, particularly epithelial malignancies, where aberrant keratin expression serves as diagnostic or prognostic biomarkers.
The KRT222P antibody enables detection via techniques like Western blotting, immunohistochemistry, or immunofluorescence, aiding in elucidating its tissue distribution and potential biological relevance. Research efforts continue to explore whether KRT222P contributes to cellular processes such as differentiation, apoptosis, or tumor progression, leveraging such antibodies to validate its expression and interactions in model systems. Challenges include verifying specificity due to pseudogene homology and clarifying its biological significance amid evolving genomic annotations.
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