| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Putative sodium-coupled neutral amino acid transporter 8, Solute carrier family 38 member 8, SLC38A8 |
| Entrez GeneID | 146167 |
| WB Predicted band size | 46.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SLC38A8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-177 amino acids from the Central region of human SLC38A8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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SLC38A8 is a member of the solute carrier family 38 (SLC38), which comprises sodium-coupled neutral amino acid transporters. Specifically, SLC38A8 is implicated in the transport of glutamine, alanine, and other small neutral amino acids across cellular membranes. It is highly expressed in the retina, brain, and other tissues, suggesting roles in nutrient supply, neurotransmission, and cellular metabolism. Research has linked SLC38A8 mutations to severe neurodevelopmental disorders, including congenital foveal hypoplasia, optic nerve anomalies, and intellectual disability, highlighting its critical function in neural and ocular development.
Antibodies targeting SLC38A8 are essential tools for studying its expression, localization, and molecular interactions. These antibodies enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize protein distribution in tissues or cultured cells. Commercially available SLC38A8 antibodies are typically raised in rabbits or mice using immunogenic peptide sequences derived from conserved regions of the protein. Validation includes specificity checks via knockout controls or siRNA knockdowns.
Recent studies utilize SLC38A8 antibodies to explore its role in diseases, such as retinal degeneration or glioblastoma, where altered amino acid transport may influence tumor growth or neuronal survival. Additionally, these antibodies aid in diagnosing genetic disorders linked to SLC38A8 dysfunction. Ongoing research aims to clarify its regulatory mechanisms and therapeutic potential, positioning SLC38A8 as a biomarker or drug target for neurological and metabolic conditions.
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