| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein spinster homolog 3, SPNS3 |
| Entrez GeneID | 201305 |
| WB Predicted band size | 54.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SPNS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 470-498 amino acids from the C-terminal region of human SPNS3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
The SPNS3 (Sphingosine-1-phosphate Transporter 3) antibody is a research tool targeting the SPNS3 protein, a member of the SPNS (Spinster homolog) family of transmembrane transporters. SPNS3 is implicated in sphingolipid metabolism, particularly in the transport of sphingosine-1-phosphate (S1P), a bioactive lipid mediator regulating diverse physiological processes, including immune cell trafficking, vascular development, and inflammatory responses. While SPNS2 is well-characterized for S1P export in lymphatic and endothelial cells, SPNS3 remains less understood, though studies suggest roles in intracellular S1P shuttling or compartmentalization. Its expression is observed in multiple tissues, including the liver, kidney, and reproductive organs, hinting at potential involvement in metabolic or reproductive functions.
Antibodies against SPNS3 are primarily used to investigate its expression patterns, subcellular localization, and interactions in cellular models or tissues. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in mechanistic studies of S1P signaling pathways. Recent interest in SPNS3 has grown due to links to diseases such as metabolic disorders and cancer, though functional insights remain limited. Developing specific SPNS3 antibodies is challenging due to protein homology within the SPNS family and low endogenous expression levels. Validation often involves knockout (KO) controls or siRNA knockdown to confirm target specificity. Continued research with SPNS3 antibodies may clarify its biological significance and therapeutic potential.
×
