| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CB1 cannabinoid receptor-interacting protein 1, CRIP-1, CNRIP1, C2orf32 |
| Entrez GeneID | 25927 |
| WB Predicted band size | 18.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CNRP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-104 amino acids from the Central region of human CNRP1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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**Background of CNRP1 Antibody**
CNRP1 (Cysteine and Histidine-Rich Protein 1), also known as CHORDC1 or CHP1. is a conserved eukaryotic protein characterized by cysteine- and histidine-rich CHORD domains, which facilitate protein-protein interactions and binding to zinc ions. It plays a regulatory role in cellular stress response pathways, particularly those involving heat shock proteins (HSPs) and the target of rapamycin (TOR) signaling network. CNRP1 is implicated in modulating chaperone-assisted protein folding, stress adaptation, and cell cycle progression.
Antibodies targeting CNRP1 are essential tools for studying its expression, localization, and interactions. They enable detection via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Research utilizing CNRP1 antibodies has highlighted its involvement in cancer biology, neurodegenerative diseases, and stress-related pathologies, where dysregulation of protein homeostasis is critical. For example, CNRP1 overexpression has been linked to tumor progression, while its downregulation may impair cellular stress resilience.
These antibodies also aid in exploring CNRP1’s role in developmental processes and its interaction with key signaling molecules, such as HSP90 and SGT1. within multi-protein complexes. Commercial CNRP1 antibodies are typically validated for specificity across human, mouse, and rat models, supporting translational research. Ongoing studies focus on its potential as a therapeutic target or biomarker in diseases associated with proteostatic dysfunction.
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