| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Probable rRNA-processing protein EBP2, EBNA1-binding protein 2, Nucleolar protein p40, EBNA1BP2, EBP2 |
| Entrez GeneID | 10969 |
| WB Predicted band size | 34.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This EBNA1BP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-302 amino acids from the C-terminal region of human EBNA1BP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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The EBNA1BP2 (Epstein-Barr nuclear antigen 1-binding protein 2) antibody is a tool used to study the EBNA1BP2 protein, also known as ERBBIP or EBP2. This protein is evolutionarily conserved and plays a role in ribosome biogenesis, specifically in rRNA processing and ribosomal subunit assembly. It interacts with Epstein-Barr virus nuclear antigen 1 (EBNA1), a viral protein critical for the replication and persistence of the Epstein-Barr virus (EBV) in host cells. EBNA1BP2's association with EBNA1 suggests a potential role in viral latency or oncogenesis, though its exact mechanism remains under investigation.
In cellular contexts, EBNA1BP2 localizes to the nucleolus and is implicated in cell proliferation, differentiation, and stress responses. Studies link it to cancer biology, particularly in malignancies associated with EBV, such as nasopharyngeal carcinoma and lymphomas. The EBNA1BP2 antibody is utilized in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect protein expression, subcellular localization, and interaction partners. Its application aids in elucidating EBNA1BP2's functional roles in ribosome biosynthesis, viral pathogenesis, and tumor development. Commercial antibodies are typically validated for specificity, often targeting conserved regions across species. Research using this antibody contributes to understanding host-virus interactions and identifying therapeutic targets for EBV-related diseases.
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