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Rabbit Polyclonal PEX14 Antibody

  • 中文名： PEX14抗体
  • 别    名： Peroxisomal membrane protein PEX14, PTS1 receptor-docking protein, Peroxin-14, Peroxisomal membrane anchor protein PEX14, PEX14
货号: IPDX31107
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPeroxisomal membrane protein PEX14, PTS1 receptor-docking protein, Peroxin-14, Peroxisomal membrane anchor protein PEX14, PEX14
Entrez GeneID5195
WB Predicted band size41.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis PEX14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-150 amino acids from the Central region of human PEX14.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇与PEX14抗体相关的文献摘要(人工整理示例，非真实文献数据)：

1. **文献名称**：PEX14 interacts with PTS1 receptor to mediate peroxisomal protein import

**作者**：Smith A et al.

**摘要**：本研究利用PEX14特异性抗体进行免疫共沉淀实验，揭示了PEX14与过氧化物酶体靶向信号受体PEX5的相互作用机制，证实其在基质蛋白转运中的核心作用。

2. **文献名称**：Structural analysis of human PEX14 reveals conserved peroxisome membrane docking domain

**作者**：Tanaka K et al.

**摘要**：通过抗PEX14多克隆抗体的免疫印迹和免疫荧光定位，首次解析了人源PEX14的N端结构域在过氧化物酶体膜锚定中的关键功能，为相关代谢疾病提供结构基础。

3. **文献名称**：Zellweger syndrome-linked PEX14 mutations impair peroxisomal matrix protein import

**作者**：Braverman N et al.

**摘要**：研究使用PEX14单克隆抗体对患者成纤维细胞进行分析，发现PEX14基因突变导致其无法与PEX5结合，从而破坏过氧化物酶体基质蛋白输入，解释了脑肝肾综合征的分子机制。

注：以上为模拟示例，实际文献需通过PubMed/Google Scholar检索关键词"PEX14 antibody"获取。

背景信息

The PEX14 antibody is a crucial tool in studying peroxisome biology, targeting the peroxisomal membrane protein PEX14. This protein serves as a central component of the peroxisomal docking/translocation machinery, facilitating the import of matrix proteins containing PTS1 (peroxisomal targeting signal 1) or PTS2 motifs. PEX14 interacts with cytosolic receptors like PEX5 and PEX7. forming a dynamic import complex with PEX13. Dysregulation of PEX14 is linked to peroxisome biogenesis disorders (e.g., Zellweger spectrum disorders), neurological defects, and metabolic dysfunction. Researchers use PEX14 antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate peroxisome abundance, protein trafficking, and molecular interactions in cell lines or tissues. These antibodies are often raised in rabbits or mice, validated for specificity across human, mouse, and rat models. Studies employing PEX14 antibodies have elucidated peroxisome-related pathways in lipid metabolism, reactive oxygen species regulation, and plasmalogen synthesis, with implications for neurodegenerative diseases, cancer, and metabolic syndromes. Commercial PEX14 antibodies typically recognize epitopes within conserved regions (e.g., the coiled-coil domain), enabling cross-species reactivity. Proper validation using PEX14-knockout controls is essential to confirm antibody specificity in experimental models.

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