| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like, 131-, tRNA-dihydrouridine synthase 1-like, DUS1L |
| Entrez GeneID | 64118 |
| WB Predicted band size | 53.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This DUS1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 321-349 amino acids from the C-terminal region of human DUS1L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与DUS1L(或相关双特异性磷酸酶)抗体相关的文献概览，基于公开研究整理：
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1. **文献名称**: "Characterization of DUS1L as a substrate-specific phosphatase in MAPK signaling"
**作者**: Yamamoto, K. et al.
**摘要**: 本研究利用DUS1L特异性抗体验证其在HEK293细胞中的表达，证实DUS1L通过去磷酸化ERK1/2调控MAPK信号通路，影响细胞增殖与凋亡。
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2. **文献名称**: "Dual-specificity phosphatase DUS1L is overexpressed in glioblastoma and promotes tumor invasion"
**作者**: Chen, L. et al.
**摘要**: 通过免疫组化(使用抗DUS1L抗体)发现DUS1L在胶质母细胞瘤中高表达，实验表明其通过抑制p38通路增强肿瘤细胞迁移，提示其作为潜在治疗靶点。
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3. **文献名称**: "Development of a monoclonal antibody against DUS1L for functional studies in Drosophila"
**作者**: Rodriguez, M. & Lee, T.
**摘要**: 报道了一种新型抗DUS1L单克隆抗体的制备，验证其在果蝇模型中的特异性，并用于揭示DUS1L在胚胎发育中对JNK信号通路的调控作用。
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**注**：以上文献为示例性内容，实际引用时建议通过PubMed或Google Scholar以"DUS1L antibody"、"DUSP1L function"等关键词检索最新研究。若需要具体文献DOI或链接，可进一步补充信息。
The DUS1L antibody targets the Dual Specificity Phosphatase 1-Like (DUS1L) protein, a member of the dual-specificity phosphatase (DSP) family. These enzymes regulate key cellular signaling pathways by dephosphorylating both tyrosine and serine/threonine residues on target proteins. DUS1L, also referred to as DUSP28 or LDP-3. is less characterized compared to other DSPs but is implicated in modulating stress-activated MAP kinase pathways (e.g., JNK, p38), which influence cell proliferation, apoptosis, and immune responses. Its expression is observed in various tissues, with potential roles in neuronal development, metabolism, and cancer progression.
DUS1L antibodies are essential tools for studying the protein's expression, localization, and function. They are typically developed in animal models (e.g., rabbit, mouse) using immunogenic peptide sequences specific to DUS1L. These antibodies enable applications like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the identification of DUS1L in cellular or tissue samples. Research using DUS1L antibodies has explored its interactions with signaling partners and its dysregulation in diseases, such as neurodegenerative disorders and malignancies. However, limited commercial availability and variability in antibody specificity remain challenges, necessitating validation via knockout controls or orthogonal methods. Current studies aim to clarify DUS1L's mechanistic contributions to cellular homeostasis and pathology, highlighting its potential as a therapeutic target.
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