| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RNA-binding protein 42, RNA-binding motif protein 42, RBM42 |
| Entrez GeneID | 79171 |
| WB Predicted band size | 50.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RBM42 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 394-422 amino acids from the C-terminal region of human RBM42. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RBM42抗体的虚构参考文献示例(仅供示例参考，非真实文献)：
1. **文献名称**：*RBM42在神经发育中的功能及其抗体特异性验证*
**作者**：Zhang L. et al.
**摘要**：本研究利用新型RBM42抗体(克隆号#AB-R42-1)在小鼠模型中揭示了RBM42蛋白在胚胎神经干细胞分化中的关键作用。通过免疫组化和Western blot验证了抗体的特异性，并发现RBM42通过调控mRNA剪接影响神经元迁移。
2. **文献名称**：*RBM42在胶质母细胞瘤中的表达及临床意义*
**作者**：Chen H. et al.
**摘要**：研究通过商业化RBM42抗体(购自Sigma-Aldrich)检测了100例胶质瘤样本，发现RBM42高表达与患者生存率下降显著相关。实验证实其通过结合致癌RNA靶点促进肿瘤侵袭，抗体特异性经siRNA敲低验证。
3. **文献名称**：*RNA结合蛋白RBM42的亚细胞定位及功能筛选*
**作者**：Wang Y. et al.
**摘要**：利用兔源多克隆RBM42抗体进行免疫荧光实验，发现RBM42主要定位于细胞核内，且在DNA损伤应激下向核仁转移。CRISPR-Cas9结合抗体验证显示，RBM42缺失导致细胞周期阻滞。
4. **文献名称**：*RBM42抗体在阿尔茨海默病模型中的应用研究*
**作者**：Kim S. et al.
**摘要**：研究使用RBM42抗体(Abcam货号#ab123)在转基因小鼠脑组织中检测到RBM42与tau蛋白的异常共定位，提示其可能参与病理性RNA-蛋白聚集体的形成，为神经退行机制提供了新视角。
(注：以上内容为模拟生成，实际文献需通过学术数据库检索确认。)
The RBM42 antibody is a research tool designed to detect the RNA-binding motif protein 42 (RBM42), a member of the RNA-binding protein family involved in post-transcriptional gene regulation. RBM42 contains conserved RNA-binding domains, including the RNA recognition motif (RRM), which enables its interaction with RNA molecules to modulate splicing, stability, and translation. It plays roles in neurodevelopment, cellular stress responses, and embryogenesis, with studies linking its dysfunction to neurological disorders and cancers.
The antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study RBM42's expression, localization, and molecular interactions. Recent research highlights its potential involvement in regulating mRNA translation under stress conditions and its association with diseases such as spinal muscular atrophy. Commercial RBM42 antibodies are typically validated for specificity and sensitivity across human, mouse, and rat models, aiding in both basic research and clinical investigations. However, variability in antibody performance across experimental conditions necessitates careful optimization. Ongoing studies aim to clarify RBM42's precise mechanisms in RNA metabolism and disease pathways, positioning this antibody as a critical reagent for exploring its biological and pathological significance.
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