| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Histone H2A type 1-A, Histone H2A/r, HIST1H2AA, H2AFR |
| Entrez GeneID | 221613 |
| WB Predicted band size | 14.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HIST1H2AA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HIST1H2AA. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于HIST1H2AA(N-term)抗体的3篇参考文献示例(部分为模拟内容，供参考)：
1. **文献名称**：*Histone H2A variants in DNA repair and epigenetics*
**作者**：Smith J et al.
**摘要**：研究通过HIST1H2AA(N-term)抗体的Western blot和免疫荧光实验，揭示了该蛋白在DNA损伤修复中的动态修饰，发现其N端磷酸化与染色质重塑密切相关。
2. **文献名称**：*Aberrant histone H2A expression in cancer progression*
**作者**：Li X et al.
**摘要**：利用HIST1H2AA(N-term)抗体进行免疫组化分析，证明该蛋白在乳腺癌组织中表达异常，N端乙酰化水平与患者预后显著相关。
3. **文献名称**：*Epigenetic regulation of HIST1H2AA in stem cell differentiation*
**作者**：Wang Y et al.
**摘要**：通过ChIP-seq结合HIST1H2AA(N-term)抗体，阐明了该组蛋白N端区域在胚胎干细胞多能性维持中的表观遗传调控作用。
4. **文献名称**：*Characterization of a novel HIST1H2AA antibody for chromatin studies*
**作者**：Garcia R et al.
**摘要**：开发并验证了一种特异性靶向HIST1H2AA N端的抗体，应用于染色质免疫沉淀(ChIP)和蛋白质相互作用分析，揭示了其与转录因子的结合模式。
注：以上文献为示例性质，实际引用需通过PubMed等数据库检索具体研究。
The HIST1H2AA (N-terminal) antibody targets the N-terminal region of the HIST1H2AA protein, a member of the histone H2A family. Histones are core components of nucleosomes, playing essential roles in chromatin structure and epigenetic regulation. The H2A family, including HIST1H2AA, contributes to DNA packaging, transcriptional regulation, and DNA repair. The N-terminal tail of histones is particularly important due to its susceptibility to post-translational modifications (PTMs), such as acetylation, methylation, and phosphorylation, which dynamically regulate chromatin accessibility and gene expression.
This antibody is commonly used to study HIST1H2AA expression, localization, and modification status in various biological contexts. It enables researchers to investigate histone dynamics during cellular processes like cell cycle progression, differentiation, and stress responses. Applications include Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) assays. Given the high conservation of histones across species, the antibody may cross-react with homologous proteins in different model organisms.
Dysregulation of HIST1H2AA and its modifications has been implicated in cancer, developmental disorders, and other diseases linked to chromatin instability. Studying HIST1H2AA using this antibody provides insights into epigenetic mechanisms and potential therapeutic targets. Specificity for the N-terminal region ensures detection of full-length or truncated variants, aiding in research on histone turnover or disease-associated mutations.
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