| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein Wnt-9a, Protein Wnt-14, WNT9A, WNT14 |
| Entrez GeneID | 7483 |
| WB Predicted band size | 40.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This WNT9A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-244 amino acids from the Central region of human WNT9A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于WNT9A抗体的3篇参考文献示例(注：文献为模拟示例，实际引用请通过学术数据库核实)：
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1. **文献名称**: *WNT9A regulates skeletal development through β-catenin-dependent signaling*
**作者**: Smith J, et al.
**摘要**: 本研究利用WNT9A特异性抗体，通过免疫组化和Western blot技术，揭示了WNT9A在小鼠长骨发育中对软骨细胞分化的调控作用，证实其通过β-catenin通路促进成骨细胞活性。
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2. **文献名称**: *A monoclonal antibody against WNT9A inhibits epithelial-mesenchymal transition in cancer models*
**作者**: Lee H, et al.
**摘要**: 开发了一种靶向WNT9A的单克隆抗体，验证了其在乳腺癌细胞系中的特异性结合能力，并证明其通过抑制WNT9A信号通路减少肿瘤细胞的迁移和侵袭。
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3. **文献名称**: *WNT9A antibody-based profiling identifies dysregulated signaling in congenital kidney defects*
**作者**: Garcia R, et al.
**摘要**: 通过免疫荧光染色结合WNT9A抗体，分析了人类胚胎肾脏组织中WNT9A的表达异常，发现其与输尿管芽分支缺陷相关，为先天性肾病的机制研究提供了依据。
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如需具体文献，建议在PubMed或Google Scholar中检索关键词“WNT9A antibody”或“WNT9A immunohistochemistry”，筛选涉及抗体应用的功能性研究或抗体开发类论文。
Wnt Family Member 9A (WNT9A) is a secreted glycoprotein belonging to the Wnt signaling pathway, which plays critical roles in embryonic development, tissue homeostasis, and cell fate determination. WNT9A specifically activates both canonical (β-catenin-dependent) and non-canonical Wnt signaling cascades, influencing processes such as skeletal morphogenesis, neural patterning, and urogenital system development. It is notably involved in joint formation, limb bud growth, and kidney tubule maturation. Dysregulation of WNT9A has been associated with congenital defects, skeletal abnormalities, and cancer progression.
WNT9A antibodies are immunological tools designed to detect and quantify WNT9A protein expression in research applications. These antibodies are typically produced in host species (e.g., rabbits, mice) using immunogenic peptide sequences specific to WNT9A. Validation often includes Western blotting, immunohistochemistry, and immunofluorescence to confirm specificity, often using knockout controls. High-quality WNT9A antibodies help researchers study its spatial-temporal expression, interaction partners, and signaling mechanisms in developmental models or disease contexts like osteoarthritis or renal dysplasia. Challenges in antibody development include addressing homology with other Wnt family members and ensuring recognition of post-translational modifications. Such reagents are vital for advancing understanding of Wnt-driven biological processes and therapeutic targeting.
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