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Rabbit Polyclonal KCNJ8(N-term) Antibody

  • 中文名： KCNJ8 (N-term)抗体
  • 别    名： ATP-sensitive inward rectifier potassium channel 8, Inward rectifier K(+) channel Kir61, Potassium channel, inwardly rectifying subfamily J member 8, uKATP-1, KCNJ8
货号: IPDX31065
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesATP-sensitive inward rectifier potassium channel 8, Inward rectifier K(+) channel Kir61, Potassium channel, inwardly rectifying subfamily J member 8, uKATP-1, KCNJ8
Entrez GeneID3764
WB Predicted band size48.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis KCNJ8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the N-terminal region of human KCNJ8.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于KCNJ8(N-term)抗体的3篇文献摘要示例(注：文献为虚构示例，仅供参考格式)：

1. **文献名称**：*KCNJ8 N-terminal antibody validation in cardiac tissue*

**作者**：Haruna Y, et al.

**摘要**：该研究验证了KCNJ8(N-term)抗体在心脏组织中的特异性，通过Western blot和免疫组化证实其能特异性识别Kir6.1蛋白的N端区域，并揭示其在心肌细胞膜上的分布与心律失常相关。

2. **文献名称**：*Role of Kir6.1 in vascular smooth muscle: Insights from antibody-based assays*

**作者**：Moriyama T, et al.

**摘要**：利用KCNJ8(N-term)抗体，研究发现Kir6.1在血管平滑肌细胞中高表达，并通过敲除模型证明其参与调节血管张力，抗体特异性通过siRNA沉默实验验证。

3. **文献名称**：*KCNJ8 antibody application in diabetic cardiomyopathy models*

**作者**：Kang S, et al.

**摘要**：该文献报道了KCNJ8(N-term)抗体在糖尿病小鼠心肌组织中的应用，证实Kir6.1表达水平与心肌缺血损伤相关，抗体特异性通过肽段阻断实验确认。

如需真实文献，建议通过PubMed或Google Scholar检索关键词“KCNJ8 antibody N-terminal”或“Kir6.1 antibody validation”获取。

背景信息

The KCNJ8 gene encodes Kir6.1. a key subunit of ATP-sensitive potassium (K_ATP) channels, which regulate cellular excitability and vascular tone by linking metabolic state to membrane potential. These channels are hetero-octamers composed of four pore-forming Kir6.x subunits (Kir6.1 or Kir6.2) and four regulatory sulfonylurea receptor (SUR) subunits. Kir6.1. predominantly expressed in vascular smooth muscle, cardiac cells, and mitochondria, plays a critical role in cardioprotection, vasodilation, and ischemic preconditioning. The KCNJ8 (N-term) antibody is designed to target the N-terminal region of Kir6.1. enabling specific detection in applications like Western blotting, immunohistochemistry, and immunofluorescence. Research using this antibody has advanced understanding of K_ATP channel dysfunction in cardiovascular diseases (e.g., hypertension, heart failure) and metabolic disorders. By focusing on the N-terminus, which contributes to channel assembly and trafficking, the antibody helps elucidate structural and regulatory mechanisms of Kir6.1. distinguishing it from the closely related Kir6.2 isoform. Its specificity is crucial for studies exploring tissue-specific channel behavior or genetic mutations linked to conditions like Cantú syndrome, a rare disorder characterized by vascular abnormalities.

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