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Rabbit Polyclonal GRIN3B Antibody

  • 中文名： GRIN3B抗体
  • 别    名： Glutamate receptor ionotropic, NMDA 3B, GluN3B, N-methyl-D-aspartate receptor subtype 3B, NMDAR3B, NR3B, GRIN3B
货号: IPDX31062
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGlutamate receptor ionotropic, NMDA 3B, GluN3B, N-methyl-D-aspartate receptor subtype 3B, NMDAR3B, NR3B, GRIN3B
Entrez GeneID116444
WB Predicted band size113.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis GRIN3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 904-933 amino acids from the C-terminal region of human GRIN3B.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于GRIN3B抗体的3篇参考文献示例(注：以下文献信息为虚构示例，仅用于演示格式)：

1. **文献名称**: "GRIN3B Subunit-Specific Antibody Characterization in Human Brain Tissue"

**作者**: Smith A, et al.

**摘要**: 本研究开发并验证了一种高特异性GRIN3B抗体，通过免疫印迹和免疫组化技术证实其在人脑组织中的表达定位，发现GRIN3B在皮层和海马区的突触后膜富集，提示其在NMDA受体复合物中的独特功能。

2. **文献名称**: "Altered GRIN3B Expression in Schizophrenia: Insights from Antibody-Based Proteomic Analysis"

**作者**: Chen L, et al.

**摘要**: 利用GRIN3B特异性抗体对精神分裂症患者脑组织进行蛋白质组学分析，发现前额叶皮层中GRIN3B蛋白水平显著降低，提示其表达异常可能与突触功能障碍相关。

3. **文献名称**: "GRIN3B Antibody Reveals Developmental Regulation of NMDA Receptor Composition"

**作者**: Park J, et al.

**摘要**: 通过GRIN3B抗体研究小鼠大脑发育过程中NMDA受体亚基的动态变化，发现GRIN3B在成年期表达上调，可能影响受体门控特性及神经可塑性。

(注：实际文献需通过PubMed或Google Scholar等平台以“GRIN3B antibody”为关键词检索获取。)

背景信息

The GRIN3B antibody is a research tool designed to detect and study the GluN3B protein, encoded by the GRIN3B gene. GluN3B is a subunit of N-methyl-D-aspartate (NMDA) receptors, a subclass of ionotropic glutamate receptors critical for synaptic plasticity, learning, and memory. Unlike conventional NMDA receptor subunits (e.g., GluN1. GluN2), GluN3B-containing receptors exhibit unique biophysical properties, such as reduced calcium permeability and voltage-dependent magnesium block, influencing their role in neuronal development and circuit refinement. GRIN3B expression is primarily observed in the central nervous system, with higher levels during early postnatal stages, suggesting involvement in developmental synaptic pruning and maturation. Dysregulation of GRIN3B has been implicated in neuropsychiatric disorders (e.g., schizophrenia, autism spectrum disorders) and neurodegenerative conditions. The GRIN3B antibody enables researchers to investigate protein localization, expression patterns, and interactions via techniques like Western blotting, immunohistochemistry, or immunoprecipitation. Its specificity is validated using knockout controls or siRNA-mediated silencing to ensure accurate detection. Studies utilizing this antibody contribute to understanding GluN3B's role in synaptic physiology, disease mechanisms, and potential therapeutic targets. Commercial GRIN3B antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes within the protein's extracellular or intracellular domains.

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