| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protocadherin alpha-C2, PCDH-alpha-C2, PCDHAC2 |
| Entrez GeneID | 56134 |
| WB Predicted band size | 109.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PCDHAC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 616-644 amino acids from the Central region of human PCDHAC2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PCDHAC2抗体的3篇文献示例(内容为虚构模拟，供参考)：
1. **文献名称**：*Protocadherin AC2 in neural circuit assembly*
**作者**：Smith J, et al.
**摘要**：研究利用PCDHAC2特异性抗体，通过免疫组织化学揭示了该蛋白在小鼠大脑皮层神经元突触形成中的表达模式，证明其参与神经元连接的精准调控。
2. **文献名称**：*PCDHAC2 antibody validation for flow cytometry applications*
**作者**：Lee H, et al.
**摘要**：本文开发并验证了一种高特异性抗PCDHAC2的单克隆抗体，证实其在流式细胞术和免疫印迹中的有效性，为肿瘤细胞表面标志物研究提供了工具。
3. **文献名称**：*Dysregulation of PCDHAC2 in autism spectrum disorders*
**作者**：Garcia R, et al.
**摘要**：通过PCDHAC2抗体检测自闭症患者脑组织样本，发现该蛋白表达异常与突触功能缺陷相关，提示其在神经发育疾病中的潜在作用。
(注：若需真实文献，建议通过PubMed或Google Scholar搜索“PCDHAC2 antibody”或“protocadherin AC2”结合实验技术关键词。)
The PCDHAC2 antibody is a tool used to detect protocadherin alpha-C2 (PCDHAC2), a member of the protocadherin alpha gene cluster within the cadherin superfamily. Protocadherins are transmembrane proteins critical for neural development, synaptic specificity, and cell-cell adhesion in the central nervous system. The PCDHA cluster, located on chromosome 5q31 in humans, consists of 15 variable exons (including PCDHAC2) and constant exons, generating diverse isoforms through combinatorial splicing. These isoforms contribute to neuronal diversity, circuit formation, and synaptic plasticity by mediating homophilic interactions.
PCDHAC2 antibodies are primarily employed in neuroscience research to study protein expression patterns, subcellular localization, and functional roles in neurodevelopmental disorders, neurodegenerative diseases, or cancer. Dysregulation of protocadherins has been linked to autism spectrum disorders, schizophrenia, and tumor metastasis. The antibody is commonly validated in techniques like immunohistochemistry, Western blotting, or immunofluorescence, often using brain tissue or neuronal cell lines. However, challenges remain in distinguishing PCDHAC2 from closely related isoforms due to high sequence homology. Recent studies also explore its potential as a biomarker or therapeutic target, emphasizing the need for antibody specificity in functional assays.
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