| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Olfactory receptor 5AS1, Olfactory receptor OR11-168, OR5AS1 |
| Entrez GeneID | 219447 |
| WB Predicted band size | 36.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OR5AS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-272 amino acids from the C-terminal region of human OR5AS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下为基于OR5AS1相关研究的模拟参考文献示例(请注意这些文献为假设性示例，实际文献需通过学术数据库验证)：
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1. **"OR5AS1 expression in cutaneous melanoma: a potential biomarker for prognosis"**
*Authors: Smith A, et al. (2020)*
**摘要**: 本研究通过免疫组化分析发现OR5AS1蛋白在黑色素瘤组织中高表达，且与患者生存率负相关。研究使用兔源多克隆OR5AS1抗体验证表达水平，提示其可能作为治疗靶点。
2. **"Olfactory receptor OR5AS1 promotes prostate cancer cell proliferation via ERK pathway"**
*Authors: Lee J, et al. (2019)*
**摘要**: 利用Western blot和免疫荧光技术(基于商业化OR5AS1单克隆抗体)，发现OR5AS1在前列腺癌细胞中异常激活ERK信号通路，促进肿瘤生长。
3. **"Non-olfactory expression of OR5AS1 in human keratinocytes and its role in wound healing"**
*Authors: Gupta R, et al. (2021)*
**摘要**: 通过抗OR5AS1抗体检测发现该受体在皮肤角质形成细胞中表达，实验表明其通过调控钙离子信号促进伤口修复，为首次揭示其在皮肤生理中的作用。
4. **"Antibody validation for olfactory receptor studies: a case study on OR5AS1"**
*Authors: Chen L, et al. (2022)*
**摘要**: 系统评估了多种OR5AS1抗体的特异性，通过siRNA敲除和质谱分析确认某品牌抗体的可靠性，为后续嗅觉受体功能研究提供工具优化方案。
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**建议**：实际研究中OR5AS1抗体相关文献可能较少，建议通过PubMed或Google Scholar以“OR5AS1 antibody”或“OR5AS1 protein expression”为关键词检索最新文献，或关注其所在嗅觉受体家族(如OR5A1等)的共性研究。
The OR5AS1 antibody is a research tool designed to detect the olfactory receptor family 5 subfamily AS member 1 (OR5AS1), a protein belonging to the G protein-coupled receptor (GPCR) superfamily. Olfactory receptors (ORs), primarily expressed in olfactory sensory neurons, are responsible for detecting odorant molecules and initiating signal transduction. While OR5AS1's specific ligand remains uncharacterized, it is hypothesized to play a role in odorant recognition. Interestingly, ORs like OR5AS1 are also found in non-olfactory tissues (e.g., testes, brain, kidneys), suggesting potential non-canonical functions in cellular processes such as chemotaxis, tissue development, or disease pathways.
The OR5AS1 antibody is typically developed using immunogenic peptides or recombinant protein fragments to ensure specificity. It is utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study OR5AS1 expression patterns, localization, and regulatory mechanisms. Its application aids in exploring OR5AS1's physiological roles, including potential contributions to diseases like cancer or neurological disorders where ectopic OR expression has been observed. However, challenges persist due to ORs' high sequence homology, requiring rigorous validation to confirm antibody specificity. Research involving OR5AS1 antibodies contributes to broader understanding of olfactory receptor biology and their extrapulmonary functions.
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