| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Glutamyl aminopeptidase, EAP, Aminopeptidase A, AP-A, Differentiation antigen gp160, CD249, ENPEP |
| Entrez GeneID | 2028 |
| WB Predicted band size | 109.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ENPEP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 899-930 amino acids from the C-terminal region of human ENPEP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于ENPEP抗体的3篇参考文献示例(文献信息为假设性示例，实际引用请核实)：
1. **文献名称**：*ENPEP as a Prognostic Biomarker in Renal Cell Carcinoma*
**作者**：Johnson A, et al.
**摘要**：研究分析了ENPEP在肾细胞癌中的表达，发现其高表达与患者不良预后相关。ENPEP抗体用于检测肿瘤组织中酶活性，提示其可能成为治疗靶点。
2. **文献名称**：*Targeting ENPEP in Tumor Angiogenesis with Neutralizing Antibodies*
**作者**：Smith B, et al.
**摘要**：探讨ENPEP抗体通过抑制血管内皮细胞中ENPEP的活性，阻断肿瘤血管生成，在小鼠模型中显著抑制肿瘤生长。
3. **文献名称**：*ENPEP Expression in Hypertensive Vascular Remodeling*
**作者**：Lee C, et al.
**摘要**：研究利用ENPEP特异性抗体发现，高血压模型中血管平滑肌细胞ENPEP表达上调，提示其在血管重构中的潜在调控作用。
(注：以上文献为模拟内容，实际研究中请通过PubMed、Google Scholar等平台检索真实论文。)
The ENPEP (glutamyl aminopeptidase) antibody is a research tool targeting the ENPEP protein, a membrane-bound metalloprotease involved in regulating bioactive peptides like angiotensin II and III. ENPEP plays critical roles in blood pressure regulation, vascular remodeling, and cellular adhesion by cleaving N-terminal amino acids from peptide hormones. Originally identified in endothelial cells, ENPEP is also expressed in kidney, liver, and immune cells. Its involvement in angiogenesis and tumor microenvironment modulation has drawn interest in cancer research, particularly in studying tumor-associated vasculature and metastasis.
ENPEP antibodies are widely used in biomedical research to detect protein expression, localization, and function via techniques like Western blot, immunohistochemistry, and flow cytometry. Recent studies link ENPEP dysregulation to diseases including hypertension, preeclampsia, and solid tumors (e.g., glioblastoma, renal cell carcinoma). In cancer contexts, ENPEP overexpression correlates with poor prognosis, suggesting its potential as a therapeutic target. Researchers also utilize these antibodies to explore ENPEP's role in endothelial-to-mesenchymal transition (EndMT) and immune cell interactions. Commercial ENPEP antibodies are typically developed in rabbit or mouse hosts, validated for specificity across human and model organism samples. Ongoing investigations focus on its mechanistic contributions to pathological processes and preclinical evaluation of ENPEP-targeted therapies.
×
