| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 593, Zinc finger protein T86, ZNF593 |
| Entrez GeneID | 51042 |
| WB Predicted band size | 15.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This ZNF593 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-88 amino acids from the Central region of human ZNF593. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF593抗体的3篇参考文献示例(注：以下为虚构示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: "ZNF593 interacts with the Oct4/Sox2 complex and regulates embryonic stem cell self-renewal"
**作者**: Zhang Y, et al.
**摘要**: 本研究利用ZNF593特异性抗体，通过免疫共沉淀(Co-IP)和染色质免疫沉淀(ChIP)技术，揭示了ZNF593与Oct4/Sox2转录复合物的相互作用，证实其在维持胚胎干细胞多能性中的调控作用。
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2. **文献名称**: "Proteomic analysis of ZNF593-associated complexes in hepatocellular carcinoma"
**作者**: Lee S, et al.
**摘要**: 通过Western blot和免疫组化(IHC)实验，使用ZNF593抗体检测其在肝癌组织中的表达水平升高，并发现其与肿瘤增殖相关蛋白的共定位，提示ZNF593可能作为肝癌的生物标志物。
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3. **文献名称**: "Characterization of a monoclonal antibody against human ZNF593 for subcellular localization studies"
**作者**: Smith J, et al.
**摘要**: 本研究开发了一种高特异性的抗ZNF593单克隆抗体，验证了其在免疫荧光(IF)和流式细胞术中的应用，证实ZNF593主要定位于细胞核，并在细胞周期调控中发挥作用。
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**备注**：若需真实文献，建议通过PubMed、Google Scholar等平台检索“ZNF593 antibody”或“ZNF593 immunodetection”，并筛选涉及抗体开发、验证或应用的实验研究。
The ZNF593 antibody is a research tool designed to detect zinc finger protein 593 (ZNF593), a member of the zinc finger protein family implicated in transcriptional regulation and protein interactions. ZNF593. also known as the "osteoclast-derived zinc finger" (OCZF), contains a C-terminal domain that facilitates interactions with other proteins, including transcriptional corepressors. It is expressed in various tissues, with roles in cellular differentiation, apoptosis, and possibly tumor suppression, though its precise biological functions remain under investigation.
Antibodies targeting ZNF593 are typically produced in immunized hosts (e.g., rabbits or mice) using synthetic peptides or recombinant protein fragments corresponding to specific epitopes. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study ZNF593 expression patterns, subcellular localization, and protein-protein interactions. Validation often includes knockout (KO) cell lines or tissues to confirm specificity.
Research involving ZNF593 antibodies has explored its potential involvement in cancers (e.g., leukemia, hepatocellular carcinoma) and neurological disorders, as well as its regulatory effects on cell cycle progression and gene expression. Commercial and custom antibodies vary in clonality (monoclonal/polyclonal), conjugates, and species reactivity (human, mouse, rat), necessitating careful selection based on experimental requirements. Ongoing studies aim to clarify its molecular mechanisms and therapeutic relevance.
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