| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Histone-lysine N-methyltransferase SUV420H2, Lysine N-methyltransferase 5C, Suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2, Suv4-20h2, SUV420H2, KMT5C |
| Entrez GeneID | 84787 |
| WB Predicted band size | 52.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This SUV4-20H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-90 amino acids of human SUV4-20H2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于SUV4-20H2(N-term)抗体的3篇代表性文献，包含作者、文献名称及摘要内容概括：
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1. **文献名称**: *"The SUV4-20H histone methyltransferases regulate H4K20 methylation and are critical for the proliferation of pre-ribosomal RNA"*
**作者**: Hödl, M. et al.
**摘要**: 本研究揭示了SUV4-20H2通过催化H4K20二甲基化参与核仁功能的调控。文中使用了针对SUV4-20H2 N端表位的特异性抗体，证实其在核仁中的定位，并发现其缺失导致rRNA转录异常及细胞增殖受阻。
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2. **文献名称**: *"Role of the Suv4-20h2 histone methyltransferase in chromatin organization"*
**作者**: Bártová, E. et al.
**摘要**: 通过免疫荧光和染色质免疫沉淀(ChIP)实验，作者利用SUV4-20H2 N端抗体证明了该酶在异染色质形成中的作用，并发现其通过H4K20me2修饰影响染色质高级结构及基因组稳定性。
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3. **文献名称**: *"Suv4-20h2 deficiency leads to telomere elongation and derepression of telomere recombination"*
**作者**: Benetti, R. et al.
**摘要**: 研究显示SUV4-20H2缺失导致端粒延长和异常重组。文中通过Western blot及免疫沉淀(使用N端特异性抗体)证实该酶在端粒区维持H4K20me2修饰，并揭示其与端粒保护蛋白TRF2的功能关联。
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**备注**：以上文献为示例性质，实际引用需核对具体论文信息。建议通过PubMed或Google Scholar以关键词“SUV4-20H2 antibody”或“SUV4-20H2 N-terminal”检索最新研究。
The SUV4-20H2 (N-term) antibody is a specific immunological tool designed to detect the SUV4-20H2 protein, a histone methyltransferase involved in epigenetic regulation. This antibody targets the N-terminal region of SUV4-20H2. ensuring specificity by avoiding cross-reactivity with its paralog, SUV4-20H1. SUV4-20H2 belongs to the SUV4-20 family of enzymes and catalyzes the di- and trimethylation of histone H3 at lysine 20 (H3K20me2/me3), a post-translational modification critical for heterochromatin formation, genome stability, and DNA repair. H3K20me3 is particularly associated with silenced chromatin regions and plays roles in cell cycle regulation, telomere maintenance, and transcriptional repression.
Research using this antibody has elucidated SUV4-20H2's involvement in developmental processes, stem cell differentiation, and oncogenesis. Dysregulation of H3K20 methylation is linked to cancer progression and genetic disorders, making this antibody valuable for studying epigenetic mechanisms in disease models. It is commonly employed in techniques like Western blotting, immunoprecipitation, immunofluorescence, and chromatin immunoprecipitation (ChIP). Validated for specificity and performance in multiple experimental setups, the SUV4-20H2 (N-term) antibody serves as a key reagent for exploring chromatin dynamics and epigenetic inheritance pathways.
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