关键信息
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基因名
NOS1AP
- 应用
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别名
NOS1AP；CAPON；KIAA0464；Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75052
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表达区间
1-506aa
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氨基酸序列
MPSKTKYNLVDDGHDLRIPLHNEDAFQHGICFEAKYVGSLDVPRPNSRVE IVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKLLLLQKKEWT WDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKK KSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSNSSGDPGR QLTGAERASTATAEETDIDAVEVPLPGNDVLEFSRGVTDLDAVGKEGGSH TGSKVSHPQEPMLTASPRMLLPSSSSKPPGLGTETPLSTHHQMQLLQQLL QQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHIS LLVKQVQELELKLSGQNAMGSQDSLLEITFRSGALPVLCDPTTPKPEDLH SPPLGAGLADFAHPAGSPLGRRDCLVKLECFRFLPPEDTPPPAQGEALLG GLELIKFRESGIASEYESNTDESEERDSWSQEELPRLLNVLQRQELGDGL DDEIAV
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分子量
83 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
NOS1AP, or neuronal nitric oxide synthase 1 associated protein, plays a critical role in the regulation of neuronal signaling and has been implicated in various neurological disorders. Research indicates that NOS1AP interacts with the nNOS enzyme, influencing nitric oxide production, which is crucial for neurotransmission and synaptic plasticity. The protein is encoded by the NOS1AP gene, located on chromosome 1, and variations in this gene have been associated with several psychiatric conditions, including schizophrenia and bipolar disorder. Given its significant role in the central nervous system, NOS1AP has emerged as a potential therapeutic target for treating these mental health issues. Additionally, studies have shown that the protein can affect cellular calcium signaling and contribute to neuroinflammatory processes, further complicating its role in neurobiology. Understanding the structure and function of NOS1AP through the development of recombinant proteins could provide valuable insights into its mechanisms and interactions, paving the way for targeted therapies. Recombinant protein studies help elucidate the protein’s functional domains, offering a clearer understanding of how it modulates neuronal behavior and contributes to the pathophysiology of various brain disorders. Overall, NOS1AP represents a compelling focus for research aimed at deciphering the intricate relationships between genetic factors and neurological health.
