关键信息
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基因名
PAIP1
- 应用
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别名
Polyadenylate-binding protein-interacting protein 1(PABP-interacting protein 1)(PAIP-1)(Poly(A)-binding protein-interacting protein 1)
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H074
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表达区间
1-479aa
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分子量
61.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
PAIP1 (Poly(A)-binding protein interacting protein 1) is a critical regulatory protein that plays a significant role in mRNA translation and stabilization. It interacts with poly(A)-binding protein (PABP), facilitating the circularization of mRNA, which enhances translation efficiency. Research has shown that PAIP1 is involved in various cellular processes, including cell growth, differentiation, and the stress response. Abnormal expression or malfunction of PAIP1 has been linked to several diseases, particularly cancer, where altered mRNA metabolism can lead to uncontrolled cell proliferation. The study of PAIP1, particularly through the generation of recombinant proteins, allows for detailed investigation of its structural and functional properties. Such research utilizes techniques like recombinant DNA technology to produce PAIP1 in various systems, enabling researchers to dissect its interactions with mRNA and other translational components. Understanding the mechanistic role of PAIP1 in gene expression has implications not only for basic biology but also for the development of therapeutic strategies targeting mRNA regulation in diseases. As such, PAIP1 is a focal point for ongoing studies aimed at unraveling the complexities of gene expression regulation and its impact on human health.
