| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AP-3 complex subunit sigma-1, AP-3 complex subunit sigma-3A, Adaptor-related protein complex 3 subunit sigma-1, Clathrin-associated/assembly/adaptor protein, small 3, Sigma-3A-adaptin, Sigma3A-adaptin, Sigma-adaptin 3a, AP3S1, CLAPS3 |
| Entrez GeneID | 1176 |
| WB Predicted band size | 21.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This AP3S1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human AP3S1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下为假设的3篇与AP3S1 (N-term)抗体相关的文献示例(实际文献请通过PubMed等数据库核实)：
1. **文献名称**：*Characterization of adaptor protein complex AP-3 subunits in neuronal cells*
**作者**：Dell'Angelica EC, et al.
**摘要**：研究解析了AP3复合体各亚基(含AP3S1)在神经元中的表达特征，利用N端特异性抗体通过免疫印迹验证AP3S1蛋白在脑组织中的分布，揭示其在突触囊泡运输中的作用。
2. **文献名称**：*AP3S1 mutations alter protein trafficking in Hermansky-Pudlak syndrome models*
**作者**：Ohno H, et al.
**摘要**：探讨AP3S1基因突变导致Hermansky-Pudlak综合征的机制，使用N-term抗体进行免疫荧光定位，发现突变后AP3S1在细胞内的错误分布影响溶酶体相关细胞器生成。
3. **文献名称**：*Functional analysis of AP-3 complex in plant vacuolar transport*
**作者**：Benson AA, et al.
**摘要**：通过植物模型研究AP3S1在液泡运输中的功能，利用N端抗体进行免疫沉淀实验，证明其与AP3其他亚基互作，调控特定膜蛋白的分选过程。
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**提示**：实际文献需通过关键词“AP3S1 antibody”、“AP3S1 N-terminal”等在PubMed/Google Scholar检索。部分研究可能聚焦于基因功能而非抗体开发，建议结合实验目的筛选文献。
The AP3S1 (N-term) antibody targets the N-terminal region of the Adaptor-Related Protein Complex 3 Sigma 1 subunit (AP3S1), a key component of the AP-3 complex involved in intracellular vesicle trafficking. The AP-3 complex mediates cargo sorting from endosomes to lysosomes and lysosome-related organelles (LROs), playing critical roles in organelle biogenesis, melanosome formation, and platelet dense granule function. AP3S1. as the σ subunit, contributes to complex assembly and cargo recognition. Mutations in AP3S1 are linked to Hermansky-Pudlak syndrome type 2 (HPS-2), a rare autosomal recessive disorder characterized by oculocutaneous albinism, bleeding disorders, and immunodeficiency.
The AP3S1 (N-term) antibody is widely used in research to study AP-3 complex localization, expression levels, and functional interactions in cellular models. It aids in detecting AP3S1 in techniques like Western blotting, immunofluorescence, and immunohistochemistry. By focusing on the N-terminal domain, this antibody helps investigate structural or regulatory regions critical for AP-3 assembly or cargo binding. Its applications extend to exploring vesicular trafficking defects, lysosomal storage disorders, and diseases associated with LRO dysfunction. Validation typically includes testing in AP3S1-knockdown or knockout systems to confirm specificity. This tool is essential for elucidating AP-3's role in cellular homeostasis and disease mechanisms.
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