| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MICAL-like protein 1, Molecule interacting with Rab13, MIRab13, MICALL1, KIAA1668, MIRAB13 |
| Entrez GeneID | 85377 |
| WB Predicted band size | 93.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MICALL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 752-781 amino acids from the C-terminal region of human MICALL1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及MICALL1抗体的文献概览(注：文献为虚构示例，实际需根据真实数据库检索)：
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1. **标题**: "MICALL1 regulates endothelial cell polarity and vascular lumen formation via interaction with RAB35"
**作者**: Zhang L, et al.
**摘要**: 本研究利用MICALL1特异性抗体，通过免疫荧光和共聚焦显微技术，揭示了MICALL1蛋白通过与RAB35相互作用，调控血管内皮细胞极性和管腔形成的分子机制，为血管发育异常相关疾病提供新靶点。
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2. **标题**: "Loss of MICALL1 promotes epithelial-mesenchymal transition in colorectal cancer"
**作者**: Tanaka K, et al.
**摘要**: 通过Western blot和免疫组化分析MICALL1抗体标记的蛋白表达水平，发现MICALL1在结直肠癌中表达下调，其缺失通过激活Wnt/β-catenin通路促进肿瘤细胞上皮-间质转化(EMT)，提示其作为抑癌基因的潜在作用。
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3. **标题**: "MICALL1 interacts with cytoskeletal proteins to maintain blood-brain barrier integrity"
**作者**: Müller S, et al.
**摘要**: 采用MICALL1抗体进行免疫共沉淀实验，发现MICALL1与β-actin和ZO-1等细胞骨架蛋白相互作用，维持血脑屏障紧密连接结构和功能，为神经退行性疾病中屏障损伤机制提供新见解。
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如需真实文献，建议在PubMed等平台检索关键词“MICALL1 antibody”或“MICALL1 function”。
MICALL1 (MICAL-L1) is a member of the MICAL (Molecular Interaction with CasL) family of proteins, which are characterized by their conserved N-terminal flavoprotein monooxygenase domain. Primarily localized to membrane compartments, including endosomes and cell-cell junctions, MICALL1 plays a critical role in membrane trafficking, cytoskeletal organization, and cellular signaling. It interacts with Rab GTPases (e.g., Rab8. Rab13) and other cytoskeletal regulators to coordinate vesicle transport, cell polarity, and tubular endosomal network formation. MICALL1 is also implicated in neurite outgrowth, epithelial cell morphogenesis, and receptor recycling (e.g., EGFR).
Antibodies targeting MICALL1 are essential tools for studying its expression, localization, and function in cellular processes. They are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to explore MICALL1's involvement in physiological and pathological contexts, including cancer metastasis, neurological disorders, and viral entry mechanisms (e.g., hepatitis C virus). Commercial MICALL1 antibodies are typically validated for specificity in human, mouse, or rat samples, with isoforms and post-translational modifications being key considerations. Research utilizing these antibodies has highlighted MICALL1's regulatory role in maintaining membrane dynamics and its potential as a therapeutic target in diseases linked to trafficking defects.
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