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Rabbit Polyclonal CLIC6 Antibody

  • 中文名: CLIC6抗体
  • 别    名: Chloride intracellular channel protein 6, Parchorin, CLIC6, CLIC1L
货号: IPDX30792
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

参考文献

以下是关于CLIC6抗体的模拟参考文献示例(内容为虚构,仅供格式参考):

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1. **文献名称**: "CLIC6 Expression in Ovarian Cancer: Role in Tumor Progression and Chemoresistance"

**作者**: Smith J, et al. (2018)

**摘要**: 本研究通过免疫组化和Western blot分析,使用特异性CLIC6抗体揭示了CLIC6在卵巢癌组织中的高表达,并发现其与化疗耐药性和患者预后不良相关。机制研究表明CLIC6通过调节细胞内膜运输促进肿瘤细胞存活。

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2. **文献名称**: "CLIC6 Localizes to Lysosomes and Regulates pH Homeostasis"

**作者**: Zhang L, et al. (2020)

**摘要**: 通过免疫荧光和共聚焦显微镜技术,作者利用CLIC6抗体证实了其在溶酶体膜上的定位。研究发现CLIC6参与溶酶体酸化和自噬过程,敲低CLIC6导致细胞代谢紊乱,提示其在细胞器功能中的关键作用。

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3. **文献名称**: "CLIC6 as a Novel Biomarker for Neuronal Apoptosis in Neurodegenerative Diseases"

**作者**: Lee H, et al. (2017)

**摘要**: 该研究通过CLIC6抗体检测阿尔茨海默病模型小鼠的脑组织,发现CLIC6在神经元凋亡过程中显著上调。实验表明CLIC6通过与Bcl-2家族蛋白相互作用调控线粒体凋亡通路。

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4. **文献名称**: "Functional Characterization of CLIC6 in Mitochondrial Membrane Dynamics"

**作者**: Garcia-Saez A, et al. (2019)

**摘要**: 使用CLIC6特异性抗体进行亚细胞分馏和免疫印迹分析,证明CLIC6在线粒体内膜中富集。研究揭示CLIC6通过调节线粒体膜电位影响能量代谢,为相关代谢疾病提供潜在治疗靶点。

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**注**: 以上文献信息为模拟生成,实际引用需以真实发表的论文为准。建议通过PubMed或Google Scholar以“CLIC6 antibody”为关键词检索最新文献。

背景信息

The chloride intracellular channel 6 (CLIC6) protein belongs to the CLIC family, a group of evolutionarily conserved proteins that exhibit dual functionality as both soluble cytoplasmic proteins and integral membrane ion channels. CLIC6. encoded by the *CLIC6* gene in humans, is implicated in intracellular chloride transport, membrane trafficking, and cellular homeostasis, though its precise physiological role remains less characterized compared to other CLIC members like CLIC1 or CLIC4. Structurally, CLIC6 contains a glutathione S-transferase (GST)-like domain and exhibits redox-sensitive channel activity. It is expressed in various tissues, including the brain, kidney, and reproductive organs, with studies suggesting roles in neuronal development, endosomal-lysosomal pathways, and cancer progression. Antibodies targeting CLIC6 are essential tools for studying its expression, localization, and function. These antibodies are typically validated using techniques such as Western blotting, immunohistochemistry, or immunofluorescence, often supported by knockout controls to confirm specificity. Challenges in CLIC6 antibody development include cross-reactivity with other CLIC family members due to structural similarities. Research utilizing CLIC6 antibodies has explored its potential as a biomarker in diseases like renal cell carcinoma or neurodegenerative disorders. However, further investigation is needed to fully elucidate its mechanistic contributions to cellular processes and pathology.

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